Cargando…

Genetic loci of beta-aminoisobutyric acid are associated with aging-related mild cognitive impairment

We studied the genetic associations of a previously developed Metabolomic Risk Score (MRS) for Mild Cognitive Impairment (MCI) and beta-aminoisobutyric acid metabolite (BAIBA)—the metabolite highlighted by results from a genome-wide association study (GWAS) of the MCI-MRS, and assessed their associa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Granot-Hershkovitz, Einat, Spitzer, Brian, Yang, Yunju, Tarraf, Wassim, Yu, Bing, Boerwinkle, Eric, Fornage, Myriam, Mosley, Thomas H., DeCarli, Charles, Kristal, Bruce S., González, Hector M., Sofer, Tamar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148805/ https://www.ncbi.nlm.nih.gov/pubmed/37120436 http://dx.doi.org/10.1038/s41398-023-02437-y

Ejemplares similares

Blood metabolites predicting mild cognitive impairment in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)
por: He, Shan, et al.
Publicado: (2022)

Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging
por: Granot-Hershkovitz, Einat, et al.
Publicado: (2023)

A polygenic risk score for Alzheimer’s disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in Hispanic/Latino adults in the U.S.
por: Sofer, Tamar, et al.
Publicado: (2023)

APOE alleles’ association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos‐investigation of neurocognitive aging (HCHS/SOL)
por: Granot‐Hershkovitz, Einat, et al.
Publicado: (2020)

Genetic associations between sleep traits and cognitive ageing outcomes in the Hispanic Community Health Study/Study of Latinos
por: Zhang, Yuan, et al.
Publicado: (2022)

AFA: Ancestry-specific allele frequency estimation in admixed populations: The Hispanic Community Health Study/Study of Latinos
por: Granot-Hershkovitz, Einat, et al.
Publicado: (2022)

Genome-wide association study of cognitive function in diverse Hispanics/Latinos: results from the Hispanic Community Health Study/Study of Latinos
por: Jian, Xueqiu, et al.
Publicado: (2020)

Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism
por: Tanianskii, Dmitrii A., et al.
Publicado: (2019)

Beta-Aminoisobutyric Acid Inhibits Hypothalamic Inflammation by Reversing Microglia Activation
por: Park, Byong Seo, et al.
Publicado: (2019)

Application of α-aminoisobutyric acid and β-aminoisobutyric acid inhibits pericarp browning of harvested longan fruit
por: Wang, Hui, et al.
Publicado: (2015)

Method comparison and estimation of causal effects of insomnia on health outcomes in a survey sampled population
por: Shahu, Anja, et al.
Publicado: (2023)

Distribution of D-3-aminoisobutyrate-pyruvate aminotransferase in the rat brain
por: Abe, Masao, et al.
Publicado: (2014)

HETEROGENEITY IN PROGRESSION OF COGNITIVE IMPAIRMENT AND VARIATIONS IN HEALTH EXPENDITURES AND HEALTH SERVICES USE
por: Tarraf, Wassim, et al.
Publicado: (2019)

Extent of Helical Induction Caused by Introducing α-Aminoisobutyric Acid into an Oligovaline Sequence
por: Tsuji, Genichiro, et al.
Publicado: (2018)

Apolipoprotein E genotypes among diverse middle-aged and older Latinos: Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)
por: González, Hector M., et al.
Publicado: (2018)

Associations between plasma branched-chain amino acids, β-aminoisobutyric acid and body composition
por: Rietman, Annemarie, et al.
Publicado: (2016)

Length-Dependent Formation of Transmembrane Pores by 3(10)-Helical α-Aminoisobutyric Acid Foldamers
por: Jones, Jennifer E., et al.
Publicado: (2015)

Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans
por: Stautemas, Jan, et al.
Publicado: (2019)

Opposing effects of clozapine and brexpiprazole on β-aminoisobutyric acid: Pathophysiology of antipsychotics-induced weight gain
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
por: Yi, Xuejie, et al.
Publicado: (2023)

A prospective study of serum metabolites and risk of ischemic stroke
por: Sun, Daokun, et al.
Publicado: (2019)

Polygenic Risk, Midlife Life's Simple 7, and Lifetime Risk of Stroke
por: Thomas, Emy A., et al.
Publicado: (2022)

Beta-aminoisobutyric acid is released by contracting human skeletal muscle and lowers insulin release from INS-1 832/3 cells by mediating mitochondrial energy metabolism
por: Barlow, Jonathan P., et al.
Publicado: (2020)

Urinary N-methylnicotinamide and β-aminoisobutyric acid predict catch-up growth in undernourished Brazilian children
por: Mayneris-Perxachs, Jordi, et al.
Publicado: (2016)

A Novel Finding of Increased ß-Aminoisobutyric Acid Levels in Classic Homocystinuria With Homocysteine-Lowering Treatment
por: Alkaissi, Hussam, et al.
Publicado: (2023)

β-Aminoisobutyric Acid Relates to Favorable Glucose Metabolism through Adiponectin in Adults with Obesity Independent of Prediabetes
por: Faiz, Habiba, et al.
Publicado: (2023)

Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study
por: Simino, Jeannette, et al.
Publicado: (2017)

MIDLIFE HEALTH FACTORS AND LATER-LIFE COGNITIVE DISEASE: RESULTS FROM THE 1998-2014 HEALTH AND RETIREMENT STUDY
por: Wu, Benson, et al.
Publicado: (2019)

LIFE-COURSE MULTI-DISCIPLINARY PREDICTORS OF DEMENTIA AMONG OLDER ADULTS
por: Kuwayama, Sayaka, et al.
Publicado: (2022)

Cardiovascular disease risk factor burden and cognition: Implications of ethnic diversity within the Hispanic Community Health Study/Study of Latinos
por: Lamar, Melissa, et al.
Publicado: (2019)

The Intersection of Race and Ethnicity, Nativity, and Sex on Cognitive Trajectories of Older Adults in the United States
por: Garcia, Marc, et al.
Publicado: (2021)

DEMENTIA TRAJECTORIES, MEDICAID COVERAGE, AND HEALTHCARE SERVICES USE
por: Tarraf, Wassim, et al.
Publicado: (2022)

β-aminoisobutyric acid attenuates LPS-induced inflammation and insulin resistance in adipocytes through AMPK-mediated pathway
por: Jung, Tae Woo, et al.
Publicado: (2018)

β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes
por: Audzeyenka, Irena, et al.
Publicado: (2023)

β‑aminoisobutyric acid ameliorates hypertensive vascular remodeling via activating the AMPK/SIRT1 pathway in VSMCs
por: Yin, Bo, et al.
Publicado: (2023)

A Candidate Gliotransmitter, L-β-Aminoisobutyrate, Contributes to Weight Gain and Metabolic Complication Induced by Atypical Antipsychotics
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Enhanced L-β-Aminoisobutyric Acid Is Involved in the Pathophysiology of Effectiveness for Treatment-Resistant Schizophrenia and Adverse Reactions of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2023)

A Novel Gliotransmitter, L-β-Aminoisobutyric Acid, Contributes to Pathophysiology of Clinical Efficacies and Adverse Reactions of Clozapine
por: Fukuyama, Kouji, et al.
Publicado: (2023)

Cerebral white matter hyperintensities on MRI and acceleration of epigenetic aging: the atherosclerosis risk in communities study
por: Raina, Abhay, et al.
Publicado: (2017)

Utility of polygenic embryo screening for disease depends on the selection strategy
por: Lencz, Todd, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nv6jpll87amnk44okiur98aern