Nucleotide exchange is sufficient for Hsp90 functions in vivo

Hsp90 is an essential eukaryotic chaperone that regulates the activity of many client proteins. Current models of Hsp90 function, which include many conformational rearrangements, specify a requirement of ATP hydrolysis. Here we confirm earlier findings that the Hsp82-E33A mutant, which binds ATP bu...

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Detalles Bibliográficos
Autores principales: Reidy, Michael, Garzillo, Kevin, Masison, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148809/
https://www.ncbi.nlm.nih.gov/pubmed/37120429
http://dx.doi.org/10.1038/s41467-023-38230-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148809/
https://www.ncbi.nlm.nih.gov/pubmed/37120429
http://dx.doi.org/10.1038/s41467-023-38230-0

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