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Recognition of an Ala-rich C-degron by the E3 ligase Pirh2

The ribosome-associated quality-control (RQC) pathway degrades aberrant nascent polypeptides arising from ribosome stalling during translation. In mammals, the E3 ligase Pirh2 mediates the degradation of aberrant nascent polypeptides by targeting the C-terminal polyalanine degrons (polyAla/C-degrons...

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Detalles Bibliográficos
Autores principales:	Wang, Xiaolu, Li, Yao, Yan, Xiaojie, Yang, Qing, Zhang, Bing, Zhang, Ying, Yuan, Xinxin, Jiang, Chenhao, Chen, Dongxing, Liu, Quanyan, Liu, Tong, Mi, Wenyi, Yu, Ying, Dong, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148881/ https://www.ncbi.nlm.nih.gov/pubmed/37120596 http://dx.doi.org/10.1038/s41467-023-38173-6

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