PPAR-γ regulates the effector function of human T helper 9 cells by promoting glycolysis

T helper 9 (T(H)9) cells promote allergic tissue inflammation and express the type 2 cytokines, IL-9 and IL-13, as well as the transcription factor, PPAR-γ. However, the functional role of PPAR-γ in human T(H)9 cells remains unknown. Here, we demonstrate that PPAR-γ drives activation-induced glycoly...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertschi, Nicole L., Steck, Oliver, Luther, Fabian, Bazzini, Cecilia, von Meyenn, Leonhard, Schärli, Stefanie, Vallone, Angela, Felser, Andrea, Keller, Irene, Friedli, Olivier, Freigang, Stefan, Begré, Nadja, Radonjic-Hoesli, Susanne, Lamos, Cristina, Gabutti, Max Philip, Benzaquen, Michael, Laimer, Markus, Simon, Dagmar, Nuoffer, Jean-Marc, Schlapbach, Christoph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148883/
https://www.ncbi.nlm.nih.gov/pubmed/37120582
http://dx.doi.org/10.1038/s41467-023-38233-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10148883/
https://www.ncbi.nlm.nih.gov/pubmed/37120582
http://dx.doi.org/10.1038/s41467-023-38233-x

Ejemplares similares