Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

BACKGROUND: Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations. CcRCC is unusual for its high frequency of epigenetic regulator mutatio...

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Detalles Bibliográficos
Autores principales: El Khoury, Louis Y., Pan, Xiaoyu, Hlady, Ryan A., Wagner, Ryan T., Shaikh, Shafiq, Wang, Liguo, Humphreys, Mitchell R., Castle, Erik P., Stanton, Melissa L., Ho, Thai H., Robertson, Keith D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149001/
https://www.ncbi.nlm.nih.gov/pubmed/37120552
http://dx.doi.org/10.1186/s13148-023-01471-3

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