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Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma

BACKGROUND: Epigenetic silencing of tumor suppressor genes (TSGs) is a key feature of oncogenesis in hepatocellular carcinoma (HCC). Liver-targeted delivery of CRISPR-activation (CRISPRa) systems makes it possible to exploit chromatin plasticity, by reprogramming transcriptional dysregulation. RESUL...

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Detalles Bibliográficos
Autores principales:	Sgro, Agustin, Cursons, Joseph, Waryah, Charlene, Woodward, Eleanor A., Foroutan, Momeneh, Lyu, Ruqian, Yeoh, George C. T., Leedman, Peter J., Blancafort, Pilar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149030/ https://www.ncbi.nlm.nih.gov/pubmed/37120619 http://dx.doi.org/10.1186/s13148-023-01482-0

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