Cargando…
Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review
Coumarin derivatives are the most used class of oral anticoagulants, and almost 1-2% of adults worldwide take it in the form of warfarin (WA) or acenocoumarol (AC). Cutaneous necrosis is a rare and severe complication of oral anticoagulant therapy. Most commonly, it occurs in the first 10 days, and...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149088/ https://www.ncbi.nlm.nih.gov/pubmed/37131576 http://dx.doi.org/10.7759/cureus.36960 |
_version_ | 1785035099813707776 |
---|---|
author | Alsahli, Maha M Shadid, Asem Al-Modayfer, Arwa Cambazard, Frederic Perrot, Jean-Luc |
author_facet | Alsahli, Maha M Shadid, Asem Al-Modayfer, Arwa Cambazard, Frederic Perrot, Jean-Luc |
author_sort | Alsahli, Maha M |
collection | PubMed |
description | Coumarin derivatives are the most used class of oral anticoagulants, and almost 1-2% of adults worldwide take it in the form of warfarin (WA) or acenocoumarol (AC). Cutaneous necrosis is a rare and severe complication of oral anticoagulant therapy. Most commonly, it occurs in the first 10 days, and the incidence peaks between the third and sixth day of starting treatment. Cutaneous necrosis due to AC therapy is underreported in the literature, and studies refer to this condition as “coumarin-induced skin necrosis”; however, this term is not totally accurate, as coumarin itself has no anticoagulant properties. We report a case of a 78-year-old female patient with AC-induced skin necrosis, who presented with cutaneous ecchymosis purpura over her face, arms, and lower extremities 3 hours after AC intake. |
format | Online Article Text |
id | pubmed-10149088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-101490882023-05-01 Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review Alsahli, Maha M Shadid, Asem Al-Modayfer, Arwa Cambazard, Frederic Perrot, Jean-Luc Cureus Dermatology Coumarin derivatives are the most used class of oral anticoagulants, and almost 1-2% of adults worldwide take it in the form of warfarin (WA) or acenocoumarol (AC). Cutaneous necrosis is a rare and severe complication of oral anticoagulant therapy. Most commonly, it occurs in the first 10 days, and the incidence peaks between the third and sixth day of starting treatment. Cutaneous necrosis due to AC therapy is underreported in the literature, and studies refer to this condition as “coumarin-induced skin necrosis”; however, this term is not totally accurate, as coumarin itself has no anticoagulant properties. We report a case of a 78-year-old female patient with AC-induced skin necrosis, who presented with cutaneous ecchymosis purpura over her face, arms, and lower extremities 3 hours after AC intake. Cureus 2023-03-31 /pmc/articles/PMC10149088/ /pubmed/37131576 http://dx.doi.org/10.7759/cureus.36960 Text en Copyright © 2023, Alsahli et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Dermatology Alsahli, Maha M Shadid, Asem Al-Modayfer, Arwa Cambazard, Frederic Perrot, Jean-Luc Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review |
title | Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review |
title_full | Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review |
title_fullStr | Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review |
title_full_unstemmed | Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review |
title_short | Cutaneous Necrosis Over the Nose and Lower Limbs Induced by Acenocoumarol: A Case Report and Literature Review |
title_sort | cutaneous necrosis over the nose and lower limbs induced by acenocoumarol: a case report and literature review |
topic | Dermatology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149088/ https://www.ncbi.nlm.nih.gov/pubmed/37131576 http://dx.doi.org/10.7759/cureus.36960 |
work_keys_str_mv | AT alsahlimaham cutaneousnecrosisoverthenoseandlowerlimbsinducedbyacenocoumarolacasereportandliteraturereview AT shadidasem cutaneousnecrosisoverthenoseandlowerlimbsinducedbyacenocoumarolacasereportandliteraturereview AT almodayferarwa cutaneousnecrosisoverthenoseandlowerlimbsinducedbyacenocoumarolacasereportandliteraturereview AT cambazardfrederic cutaneousnecrosisoverthenoseandlowerlimbsinducedbyacenocoumarolacasereportandliteraturereview AT perrotjeanluc cutaneousnecrosisoverthenoseandlowerlimbsinducedbyacenocoumarolacasereportandliteraturereview |