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Possible association of keratoconus progression with gender-affirming hormone therapy: A case report
PURPOSE: To present a case of keratoconus progression following gender-affirming hormone therapy. OBSERVATIONS: A 28-year-old male-to-female transgender patient with potential past ocular history of subclinical keratoconus presented with subacute worsening myopia of both eyes (OU), 4 months after in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149176/ https://www.ncbi.nlm.nih.gov/pubmed/37131527 http://dx.doi.org/10.1016/j.ajoc.2023.101850 |
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author | Deitel, Carli M. Chen, Kevin H. Uber, Ian C. |
author_facet | Deitel, Carli M. Chen, Kevin H. Uber, Ian C. |
author_sort | Deitel, Carli M. |
collection | PubMed |
description | PURPOSE: To present a case of keratoconus progression following gender-affirming hormone therapy. OBSERVATIONS: A 28-year-old male-to-female transgender patient with potential past ocular history of subclinical keratoconus presented with subacute worsening myopia of both eyes (OU), 4 months after initiation of gender-affirming hormone therapy. A diagnosis of keratoconus was established based on slit-lamp exam and computerized corneal tomography. Notable indices were central corneal thinning and inferior steepening OU with maximum corneal curvatures of 58.3 D of the right eye (OD) and 77.7 D of the left eye (OS) and thinnest corneal thickness of 440 μm OD and 397 μm OS. After 8 months of continued hormone therapy, the patient's keratoconus continued to progress and thus corneal crosslinking was recommended and performed. CONCLUSIONS: Keratoconus progression and relapse has been suggested to have an association with sex hormone changes. We report a case of keratoconus progression following gender-affirming hormone therapy in a transgender patient. Our findings continue to support a correlative relationship between sex hormones and corneal ectasia pathophysiology. Further studies are needed to determine causality and to investigate the utility of screening corneal structure prior to the initiation of gender-affirming hormone therapies. |
format | Online Article Text |
id | pubmed-10149176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101491762023-05-01 Possible association of keratoconus progression with gender-affirming hormone therapy: A case report Deitel, Carli M. Chen, Kevin H. Uber, Ian C. Am J Ophthalmol Case Rep Case Report PURPOSE: To present a case of keratoconus progression following gender-affirming hormone therapy. OBSERVATIONS: A 28-year-old male-to-female transgender patient with potential past ocular history of subclinical keratoconus presented with subacute worsening myopia of both eyes (OU), 4 months after initiation of gender-affirming hormone therapy. A diagnosis of keratoconus was established based on slit-lamp exam and computerized corneal tomography. Notable indices were central corneal thinning and inferior steepening OU with maximum corneal curvatures of 58.3 D of the right eye (OD) and 77.7 D of the left eye (OS) and thinnest corneal thickness of 440 μm OD and 397 μm OS. After 8 months of continued hormone therapy, the patient's keratoconus continued to progress and thus corneal crosslinking was recommended and performed. CONCLUSIONS: Keratoconus progression and relapse has been suggested to have an association with sex hormone changes. We report a case of keratoconus progression following gender-affirming hormone therapy in a transgender patient. Our findings continue to support a correlative relationship between sex hormones and corneal ectasia pathophysiology. Further studies are needed to determine causality and to investigate the utility of screening corneal structure prior to the initiation of gender-affirming hormone therapies. Elsevier 2023-04-18 /pmc/articles/PMC10149176/ /pubmed/37131527 http://dx.doi.org/10.1016/j.ajoc.2023.101850 Text en © 2023 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Deitel, Carli M. Chen, Kevin H. Uber, Ian C. Possible association of keratoconus progression with gender-affirming hormone therapy: A case report |
title | Possible association of keratoconus progression with gender-affirming hormone therapy: A case report |
title_full | Possible association of keratoconus progression with gender-affirming hormone therapy: A case report |
title_fullStr | Possible association of keratoconus progression with gender-affirming hormone therapy: A case report |
title_full_unstemmed | Possible association of keratoconus progression with gender-affirming hormone therapy: A case report |
title_short | Possible association of keratoconus progression with gender-affirming hormone therapy: A case report |
title_sort | possible association of keratoconus progression with gender-affirming hormone therapy: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149176/ https://www.ncbi.nlm.nih.gov/pubmed/37131527 http://dx.doi.org/10.1016/j.ajoc.2023.101850 |
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