De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report

The transformation to SCLC is a known mechanism of resistance against molecularly targeted therapies. This study reports a patient with untreated lung adenocarcinoma, characterized by a KRAS G12C mutation, which transformed into SCLC before treatment. Both the adenocarcinoma and SCLC components were...

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Detalles Bibliográficos
Autores principales: Ito, Takanori, Oi, Issei, Saito, Zentaro, Imakita, Takuma, Kanai, Osamu, Fujita, Kohei, Tachibana, Hiromasa, Moriyoshi, Koki, Mio, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149245/
https://www.ncbi.nlm.nih.gov/pubmed/37131995
http://dx.doi.org/10.1016/j.jtocrr.2023.100510
Descripción
Sumario:The transformation to SCLC is a known mechanism of resistance against molecularly targeted therapies. This study reports a patient with untreated lung adenocarcinoma, characterized by a KRAS G12C mutation, which transformed into SCLC before treatment. Both the adenocarcinoma and SCLC components were responsive to sotorasib.

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