De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report

The transformation to SCLC is a known mechanism of resistance against molecularly targeted therapies. This study reports a patient with untreated lung adenocarcinoma, characterized by a KRAS G12C mutation, which transformed into SCLC before treatment. Both the adenocarcinoma and SCLC components were...

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Autores principales: Ito, Takanori, Oi, Issei, Saito, Zentaro, Imakita, Takuma, Kanai, Osamu, Fujita, Kohei, Tachibana, Hiromasa, Moriyoshi, Koki, Mio, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149245/
https://www.ncbi.nlm.nih.gov/pubmed/37131995
http://dx.doi.org/10.1016/j.jtocrr.2023.100510
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author Ito, Takanori
Oi, Issei
Saito, Zentaro
Imakita, Takuma
Kanai, Osamu
Fujita, Kohei
Tachibana, Hiromasa
Moriyoshi, Koki
Mio, Tadashi
author_facet Ito, Takanori
Oi, Issei
Saito, Zentaro
Imakita, Takuma
Kanai, Osamu
Fujita, Kohei
Tachibana, Hiromasa
Moriyoshi, Koki
Mio, Tadashi
author_sort Ito, Takanori
collection PubMed
description The transformation to SCLC is a known mechanism of resistance against molecularly targeted therapies. This study reports a patient with untreated lung adenocarcinoma, characterized by a KRAS G12C mutation, which transformed into SCLC before treatment. Both the adenocarcinoma and SCLC components were responsive to sotorasib.
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spelling pubmed-101492452023-05-01 De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report Ito, Takanori Oi, Issei Saito, Zentaro Imakita, Takuma Kanai, Osamu Fujita, Kohei Tachibana, Hiromasa Moriyoshi, Koki Mio, Tadashi JTO Clin Res Rep Case Report The transformation to SCLC is a known mechanism of resistance against molecularly targeted therapies. This study reports a patient with untreated lung adenocarcinoma, characterized by a KRAS G12C mutation, which transformed into SCLC before treatment. Both the adenocarcinoma and SCLC components were responsive to sotorasib. Elsevier 2023-03-29 /pmc/articles/PMC10149245/ /pubmed/37131995 http://dx.doi.org/10.1016/j.jtocrr.2023.100510 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Ito, Takanori
Oi, Issei
Saito, Zentaro
Imakita, Takuma
Kanai, Osamu
Fujita, Kohei
Tachibana, Hiromasa
Moriyoshi, Koki
Mio, Tadashi
De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report
title De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report
title_full De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report
title_fullStr De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report
title_full_unstemmed De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report
title_short De Novo SCLC Transformation From KRAS G12C-Mutated Lung Adenocarcinoma With Excellent Response to Sotorasib: A Case Report
title_sort de novo sclc transformation from kras g12c-mutated lung adenocarcinoma with excellent response to sotorasib: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149245/
https://www.ncbi.nlm.nih.gov/pubmed/37131995
http://dx.doi.org/10.1016/j.jtocrr.2023.100510
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