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Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
Radiotherapy causes a series of side effects in patients with malignant tumors. Polygonati Rhizoma, Achyranthis Bidentatae Radix, and Epimedii Folium are all traditional Chinese herbs with varieties of functions such as anti-radiation and immune regulation. In this study, the above three herbs were...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149268/ https://www.ncbi.nlm.nih.gov/pubmed/37131450 http://dx.doi.org/10.1016/j.heliyon.2023.e15473 |
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author | Zheng, Tianyu Shi, Xiaohui Nie, Shuang Yin, Lifeng Zhu, Jian Yu, Enda Shen, Hui Mo, Fengfeng |
author_facet | Zheng, Tianyu Shi, Xiaohui Nie, Shuang Yin, Lifeng Zhu, Jian Yu, Enda Shen, Hui Mo, Fengfeng |
author_sort | Zheng, Tianyu |
collection | PubMed |
description | Radiotherapy causes a series of side effects in patients with malignant tumors. Polygonati Rhizoma, Achyranthis Bidentatae Radix, and Epimedii Folium are all traditional Chinese herbs with varieties of functions such as anti-radiation and immune regulation. In this study, the above three herbs were used as a herbal diet to study their effects on the hematopoietic, immune, and intestinal systems of mice exposed to three doses of radiation. Our study showed that the diet had no radiation-protective effect on the hematopoietic and immune systems. However, at the radiation dose of 4 Gy and 8 Gy, the diet showed an obvious radiation-protective effect on intestinal crypts. At the dose of 8 Gy, we also found that the Chinese herbal diet had an anti-radiation effect on reducing the loss of the inhibitory nNOS(+) neurons in the intestine. That provides a new diet for relieving the symptoms of hyperperistalsis and diarrhea in patients after radiotherapy. |
format | Online Article Text |
id | pubmed-10149268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101492682023-05-01 Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation Zheng, Tianyu Shi, Xiaohui Nie, Shuang Yin, Lifeng Zhu, Jian Yu, Enda Shen, Hui Mo, Fengfeng Heliyon Research Article Radiotherapy causes a series of side effects in patients with malignant tumors. Polygonati Rhizoma, Achyranthis Bidentatae Radix, and Epimedii Folium are all traditional Chinese herbs with varieties of functions such as anti-radiation and immune regulation. In this study, the above three herbs were used as a herbal diet to study their effects on the hematopoietic, immune, and intestinal systems of mice exposed to three doses of radiation. Our study showed that the diet had no radiation-protective effect on the hematopoietic and immune systems. However, at the radiation dose of 4 Gy and 8 Gy, the diet showed an obvious radiation-protective effect on intestinal crypts. At the dose of 8 Gy, we also found that the Chinese herbal diet had an anti-radiation effect on reducing the loss of the inhibitory nNOS(+) neurons in the intestine. That provides a new diet for relieving the symptoms of hyperperistalsis and diarrhea in patients after radiotherapy. Elsevier 2023-04-18 /pmc/articles/PMC10149268/ /pubmed/37131450 http://dx.doi.org/10.1016/j.heliyon.2023.e15473 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Zheng, Tianyu Shi, Xiaohui Nie, Shuang Yin, Lifeng Zhu, Jian Yu, Enda Shen, Hui Mo, Fengfeng Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
title | Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
title_full | Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
title_fullStr | Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
title_full_unstemmed | Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
title_short | Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
title_sort | effects of chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149268/ https://www.ncbi.nlm.nih.gov/pubmed/37131450 http://dx.doi.org/10.1016/j.heliyon.2023.e15473 |
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