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Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation

Radiotherapy causes a series of side effects in patients with malignant tumors. Polygonati Rhizoma, Achyranthis Bidentatae Radix, and Epimedii Folium are all traditional Chinese herbs with varieties of functions such as anti-radiation and immune regulation. In this study, the above three herbs were...

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Detalles Bibliográficos
Autores principales: Zheng, Tianyu, Shi, Xiaohui, Nie, Shuang, Yin, Lifeng, Zhu, Jian, Yu, Enda, Shen, Hui, Mo, Fengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149268/
https://www.ncbi.nlm.nih.gov/pubmed/37131450
http://dx.doi.org/10.1016/j.heliyon.2023.e15473
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author Zheng, Tianyu
Shi, Xiaohui
Nie, Shuang
Yin, Lifeng
Zhu, Jian
Yu, Enda
Shen, Hui
Mo, Fengfeng
author_facet Zheng, Tianyu
Shi, Xiaohui
Nie, Shuang
Yin, Lifeng
Zhu, Jian
Yu, Enda
Shen, Hui
Mo, Fengfeng
author_sort Zheng, Tianyu
collection PubMed
description Radiotherapy causes a series of side effects in patients with malignant tumors. Polygonati Rhizoma, Achyranthis Bidentatae Radix, and Epimedii Folium are all traditional Chinese herbs with varieties of functions such as anti-radiation and immune regulation. In this study, the above three herbs were used as a herbal diet to study their effects on the hematopoietic, immune, and intestinal systems of mice exposed to three doses of radiation. Our study showed that the diet had no radiation-protective effect on the hematopoietic and immune systems. However, at the radiation dose of 4 Gy and 8 Gy, the diet showed an obvious radiation-protective effect on intestinal crypts. At the dose of 8 Gy, we also found that the Chinese herbal diet had an anti-radiation effect on reducing the loss of the inhibitory nNOS(+) neurons in the intestine. That provides a new diet for relieving the symptoms of hyperperistalsis and diarrhea in patients after radiotherapy.
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spelling pubmed-101492682023-05-01 Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation Zheng, Tianyu Shi, Xiaohui Nie, Shuang Yin, Lifeng Zhu, Jian Yu, Enda Shen, Hui Mo, Fengfeng Heliyon Research Article Radiotherapy causes a series of side effects in patients with malignant tumors. Polygonati Rhizoma, Achyranthis Bidentatae Radix, and Epimedii Folium are all traditional Chinese herbs with varieties of functions such as anti-radiation and immune regulation. In this study, the above three herbs were used as a herbal diet to study their effects on the hematopoietic, immune, and intestinal systems of mice exposed to three doses of radiation. Our study showed that the diet had no radiation-protective effect on the hematopoietic and immune systems. However, at the radiation dose of 4 Gy and 8 Gy, the diet showed an obvious radiation-protective effect on intestinal crypts. At the dose of 8 Gy, we also found that the Chinese herbal diet had an anti-radiation effect on reducing the loss of the inhibitory nNOS(+) neurons in the intestine. That provides a new diet for relieving the symptoms of hyperperistalsis and diarrhea in patients after radiotherapy. Elsevier 2023-04-18 /pmc/articles/PMC10149268/ /pubmed/37131450 http://dx.doi.org/10.1016/j.heliyon.2023.e15473 Text en © 2023 Published by Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Zheng, Tianyu
Shi, Xiaohui
Nie, Shuang
Yin, Lifeng
Zhu, Jian
Yu, Enda
Shen, Hui
Mo, Fengfeng
Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
title Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
title_full Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
title_fullStr Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
title_full_unstemmed Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
title_short Effects of Chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
title_sort effects of chinese herbal diet on hematopoiesis, immunity, and intestines of mice exposed to different doses of radiation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149268/
https://www.ncbi.nlm.nih.gov/pubmed/37131450
http://dx.doi.org/10.1016/j.heliyon.2023.e15473
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