The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of ferroptosis include FSP-1 and the selenoprotein GPX4, the latter of which directly enzymatically reduces lipid hydroperoxi...

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Detalles Bibliográficos
Autores principales: Cheff, Dorian M., Huang, Chuying, Scholzen, Karoline C., Gencheva, Radosveta, Ronzetti, Michael H., Cheng, Qing, Hall, Matthew D., Arnér, Elias S.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149367/
https://www.ncbi.nlm.nih.gov/pubmed/37087975
http://dx.doi.org/10.1016/j.redox.2023.102703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149367/
https://www.ncbi.nlm.nih.gov/pubmed/37087975
http://dx.doi.org/10.1016/j.redox.2023.102703

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