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Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study
There are few radiogenomic studies to correlate ultrasound features of breast cancer with genomic changes. We investigated whether vascular ultrasound phenotypes are associated with breast cancer gene profiles for predicting angiogenesis and prognosis. We prospectively correlated quantitative and qu...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149538/ https://www.ncbi.nlm.nih.gov/pubmed/37120792 http://dx.doi.org/10.1007/s12672-023-00657-8 |
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author | Han, Mi-Ryung Park, Ah Young Seo, Bo Kyoung Bae, Min Sun Kim, Jung Sun Son, Gil Soo Lee, Hye Yoon Chang, Young Woo Cho, Kyu Ran Song, Sung Eun Woo, Ok Hee Ju, Hye-Yeon Oh, Hyunseung |
author_facet | Han, Mi-Ryung Park, Ah Young Seo, Bo Kyoung Bae, Min Sun Kim, Jung Sun Son, Gil Soo Lee, Hye Yoon Chang, Young Woo Cho, Kyu Ran Song, Sung Eun Woo, Ok Hee Ju, Hye-Yeon Oh, Hyunseung |
author_sort | Han, Mi-Ryung |
collection | PubMed |
description | There are few radiogenomic studies to correlate ultrasound features of breast cancer with genomic changes. We investigated whether vascular ultrasound phenotypes are associated with breast cancer gene profiles for predicting angiogenesis and prognosis. We prospectively correlated quantitative and qualitative features of microvascular ultrasound (vascular index, vessel morphology, distribution, and penetrating vessel) and contrast-enhanced ultrasound (time–intensity curve parameters and enhancement pattern) with genomic characteristics in 31 breast cancers. DNA obtained from breast tumors and normal tissues were analyzed using targeted next-generation sequencing of 105 genes. The single-variant association test was used to identify correlations between vascular ultrasound features and genomic profiles. Chi-square analysis was used to detect single nucleotide polymorphisms (SNPs) associated with ultrasound features by estimating p values and odds ratios (ORs). Eight ultrasound features were significantly associated with 9 SNPs (p < 0.05). Among them, four ultrasound features were positively associated with 5 SNPs: high vascular index with rs1136201 in ERBB2 (p = 0.04, OR = 7.75); large area under the curve on contrast-enhanced ultrasound with rs35597368 in PDGFRA (p = 0.04, OR = 4.07); high peak intensity with rs35597368 in PDGFRA (p = 0.049, OR = 4.05) and rs2305948 in KDR (p = 0.04, OR = 5.10); and long mean transit time with rs2275237 in ARNT (p = 0.02, OR = 10.25) and rs755793 in FGFR2 (p = 0.02, OR = 10.25). We identified 198 non-silent SNPs in 71 various cancer-related genes. Vascular ultrasound features can reflect genomic changes associated with angiogenesis and prognosis in breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12672-023-00657-8. |
format | Online Article Text |
id | pubmed-10149538 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-101495382023-05-02 Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study Han, Mi-Ryung Park, Ah Young Seo, Bo Kyoung Bae, Min Sun Kim, Jung Sun Son, Gil Soo Lee, Hye Yoon Chang, Young Woo Cho, Kyu Ran Song, Sung Eun Woo, Ok Hee Ju, Hye-Yeon Oh, Hyunseung Discov Oncol Brief Communication There are few radiogenomic studies to correlate ultrasound features of breast cancer with genomic changes. We investigated whether vascular ultrasound phenotypes are associated with breast cancer gene profiles for predicting angiogenesis and prognosis. We prospectively correlated quantitative and qualitative features of microvascular ultrasound (vascular index, vessel morphology, distribution, and penetrating vessel) and contrast-enhanced ultrasound (time–intensity curve parameters and enhancement pattern) with genomic characteristics in 31 breast cancers. DNA obtained from breast tumors and normal tissues were analyzed using targeted next-generation sequencing of 105 genes. The single-variant association test was used to identify correlations between vascular ultrasound features and genomic profiles. Chi-square analysis was used to detect single nucleotide polymorphisms (SNPs) associated with ultrasound features by estimating p values and odds ratios (ORs). Eight ultrasound features were significantly associated with 9 SNPs (p < 0.05). Among them, four ultrasound features were positively associated with 5 SNPs: high vascular index with rs1136201 in ERBB2 (p = 0.04, OR = 7.75); large area under the curve on contrast-enhanced ultrasound with rs35597368 in PDGFRA (p = 0.04, OR = 4.07); high peak intensity with rs35597368 in PDGFRA (p = 0.049, OR = 4.05) and rs2305948 in KDR (p = 0.04, OR = 5.10); and long mean transit time with rs2275237 in ARNT (p = 0.02, OR = 10.25) and rs755793 in FGFR2 (p = 0.02, OR = 10.25). We identified 198 non-silent SNPs in 71 various cancer-related genes. Vascular ultrasound features can reflect genomic changes associated with angiogenesis and prognosis in breast cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12672-023-00657-8. Springer US 2023-04-30 /pmc/articles/PMC10149538/ /pubmed/37120792 http://dx.doi.org/10.1007/s12672-023-00657-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Brief Communication Han, Mi-Ryung Park, Ah Young Seo, Bo Kyoung Bae, Min Sun Kim, Jung Sun Son, Gil Soo Lee, Hye Yoon Chang, Young Woo Cho, Kyu Ran Song, Sung Eun Woo, Ok Hee Ju, Hye-Yeon Oh, Hyunseung Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study |
title | Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study |
title_full | Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study |
title_fullStr | Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study |
title_full_unstemmed | Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study |
title_short | Association between vascular ultrasound features and DNA sequencing in breast cancer: a preliminary study |
title_sort | association between vascular ultrasound features and dna sequencing in breast cancer: a preliminary study |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149538/ https://www.ncbi.nlm.nih.gov/pubmed/37120792 http://dx.doi.org/10.1007/s12672-023-00657-8 |
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