Cargando…
Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder
BACKGROUND: Parental divorce and discord are associated with poorer alcohol-related outcomes for offspring. However, not all children exposed to these stressors develop alcohol problems. Our objective was to test gene-by-environment interaction effects whereby children’s genetic risk for alcohol pro...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149624/ https://www.ncbi.nlm.nih.gov/pubmed/36807915 http://dx.doi.org/10.1111/acer.15042 |
_version_ | 1785035181052133376 |
---|---|
author | Kuo, Sally I-Chun Thomas, Nathaniel S. Aliev, Fazil Bucholz, Kathleen K. Dick, Danielle M. McCutcheon, Vivia V. Meyers, Jacquelyn L. Chan, Grace Kamarajan, Chella Kramer, John R. Hesselbrock, Victor Plawecki, Martin H. Porjesz, Bernice Tischfield, Jay Salvatore, Jessica E. |
author_facet | Kuo, Sally I-Chun Thomas, Nathaniel S. Aliev, Fazil Bucholz, Kathleen K. Dick, Danielle M. McCutcheon, Vivia V. Meyers, Jacquelyn L. Chan, Grace Kamarajan, Chella Kramer, John R. Hesselbrock, Victor Plawecki, Martin H. Porjesz, Bernice Tischfield, Jay Salvatore, Jessica E. |
author_sort | Kuo, Sally I-Chun |
collection | PubMed |
description | BACKGROUND: Parental divorce and discord are associated with poorer alcohol-related outcomes for offspring. However, not all children exposed to these stressors develop alcohol problems. Our objective was to test gene-by-environment interaction effects whereby children’s genetic risk for alcohol problems modifies the effects of parental divorce and discord to predict alcohol outcomes. METHODS: The sample included European (EA; N = 5608, 47% male, M(age) ~ 36 years) and African (AA; N = 1714, 46% female, M(age) ~ 33 years) ancestry participants from the Collaborative Study on the Genetics of Alcoholism. Outcomes included age at initiation of regular drinking and lifetime DSM-5 alcohol use disorder (AUD). Predictors included parental divorce, parental relationship discord, and offspring alcohol problems polygenic risk scores (PRS(ALC)). Mixed effects Cox proportional hazard models were used to examine alcohol initiation and generalized linear mixed effects models were used to examine lifetime AUD. Tests of PRS moderation of the effects of parental divorce/relationship discord on alcohol outcomes were examined on multiplicative and additive scales. RESULTS: Among EA participants, parental divorce, parental discord, and higher PRS(ALC) were associated with earlier alcohol initiation and greater lifetime AUD risk. Among AA participants, parental divorce was associated with earlier alcohol initiation and discord was associated with earlier initiation and AUD. PRS(ALC) was not associated with either. Parental divorce/discord and PRS(ALC) interacted on an additive scale in the EA sample, but no interactions were found in AA participants. CONCLUSIONS: Children’s genetic risk for alcohol problems modifies the impact of parental divorce/discord, consistent with an additive model of diathesis-stress interaction, with some differences across ancestry. |
format | Online Article Text |
id | pubmed-10149624 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-101496242023-05-01 Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder Kuo, Sally I-Chun Thomas, Nathaniel S. Aliev, Fazil Bucholz, Kathleen K. Dick, Danielle M. McCutcheon, Vivia V. Meyers, Jacquelyn L. Chan, Grace Kamarajan, Chella Kramer, John R. Hesselbrock, Victor Plawecki, Martin H. Porjesz, Bernice Tischfield, Jay Salvatore, Jessica E. Alcohol (Hanover) Article BACKGROUND: Parental divorce and discord are associated with poorer alcohol-related outcomes for offspring. However, not all children exposed to these stressors develop alcohol problems. Our objective was to test gene-by-environment interaction effects whereby children’s genetic risk for alcohol problems modifies the effects of parental divorce and discord to predict alcohol outcomes. METHODS: The sample included European (EA; N = 5608, 47% male, M(age) ~ 36 years) and African (AA; N = 1714, 46% female, M(age) ~ 33 years) ancestry participants from the Collaborative Study on the Genetics of Alcoholism. Outcomes included age at initiation of regular drinking and lifetime DSM-5 alcohol use disorder (AUD). Predictors included parental divorce, parental relationship discord, and offspring alcohol problems polygenic risk scores (PRS(ALC)). Mixed effects Cox proportional hazard models were used to examine alcohol initiation and generalized linear mixed effects models were used to examine lifetime AUD. Tests of PRS moderation of the effects of parental divorce/relationship discord on alcohol outcomes were examined on multiplicative and additive scales. RESULTS: Among EA participants, parental divorce, parental discord, and higher PRS(ALC) were associated with earlier alcohol initiation and greater lifetime AUD risk. Among AA participants, parental divorce was associated with earlier alcohol initiation and discord was associated with earlier initiation and AUD. PRS(ALC) was not associated with either. Parental divorce/discord and PRS(ALC) interacted on an additive scale in the EA sample, but no interactions were found in AA participants. CONCLUSIONS: Children’s genetic risk for alcohol problems modifies the impact of parental divorce/discord, consistent with an additive model of diathesis-stress interaction, with some differences across ancestry. 2023-04 2023-03-05 /pmc/articles/PMC10149624/ /pubmed/36807915 http://dx.doi.org/10.1111/acer.15042 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Article Kuo, Sally I-Chun Thomas, Nathaniel S. Aliev, Fazil Bucholz, Kathleen K. Dick, Danielle M. McCutcheon, Vivia V. Meyers, Jacquelyn L. Chan, Grace Kamarajan, Chella Kramer, John R. Hesselbrock, Victor Plawecki, Martin H. Porjesz, Bernice Tischfield, Jay Salvatore, Jessica E. Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
title | Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
title_full | Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
title_fullStr | Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
title_full_unstemmed | Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
title_short | Association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
title_sort | association of parental divorce, discord, and polygenic risk with children’s alcohol initiation and lifetime risk for alcohol use disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149624/ https://www.ncbi.nlm.nih.gov/pubmed/36807915 http://dx.doi.org/10.1111/acer.15042 |
work_keys_str_mv | AT kuosallyichun associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT thomasnathaniels associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT alievfazil associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT bucholzkathleenk associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT dickdaniellem associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT mccutcheonviviav associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT meyersjacquelynl associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT changrace associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT kamarajanchella associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT kramerjohnr associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT hesselbrockvictor associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT plaweckimartinh associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT porjeszbernice associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT tischfieldjay associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder AT salvatorejessicae associationofparentaldivorcediscordandpolygenicriskwithchildrensalcoholinitiationandlifetimeriskforalcoholusedisorder |