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Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study

BACKGROUND: Methadone maintenance treatment (MMT) is a common treatment for heroin use disorder (HUD). Although individuals with HUD have been reported to show impaired coupling among the salience network (SN), executive control network (ECN), and default mode network (DMN), the effects of MMT on th...

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Autores principales: Chen, Jiajie, Li, Yongbin, Wang, Shu, Li, Wei, Liu, Yan, Jin, Long, Li, Zhe, Zhu, Jia, Wang, Fan, Liu, Wei, Xue, Jiuhua, Shi, Hong, Wang, Wei, Jin, Chenwang, Li, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149709/
https://www.ncbi.nlm.nih.gov/pubmed/37139328
http://dx.doi.org/10.3389/fpsyt.2023.1132407
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author Chen, Jiajie
Li, Yongbin
Wang, Shu
Li, Wei
Liu, Yan
Jin, Long
Li, Zhe
Zhu, Jia
Wang, Fan
Liu, Wei
Xue, Jiuhua
Shi, Hong
Wang, Wei
Jin, Chenwang
Li, Qiang
author_facet Chen, Jiajie
Li, Yongbin
Wang, Shu
Li, Wei
Liu, Yan
Jin, Long
Li, Zhe
Zhu, Jia
Wang, Fan
Liu, Wei
Xue, Jiuhua
Shi, Hong
Wang, Wei
Jin, Chenwang
Li, Qiang
author_sort Chen, Jiajie
collection PubMed
description BACKGROUND: Methadone maintenance treatment (MMT) is a common treatment for heroin use disorder (HUD). Although individuals with HUD have been reported to show impaired coupling among the salience network (SN), executive control network (ECN), and default mode network (DMN), the effects of MMT on the coupling among three large-scale networks in individuals with HUD remains unclear. METHODS: Thirty-seven individuals with HUD undergoing MMT and 57 healthy controls were recruited. The longitudinal one-year follow-up study aimed to evaluate the effects of methadone on anxiety, depression, withdrawal symptoms and craving and number of relapse, and brain function (SN, DMN and bilateral ECN) in relation to heroin dependence. The changes in psychological characteristics and the coupling among large-scale networks after 1 year of MMT were analyzed. The associations between the changes in coupling among large-scale networks and psychological characteristics and the methadone dose were also examined. RESULTS: After 1 year of MMT, individuals with HUD showed a reduction in the withdrawal symptom score. The number of relapses was negatively correlated with the methadone dose over 1 year. The functional connectivity between the medial prefrontal cortex (mPFC) and the left middle temporal gyrus (MTG; both key nodes of the DMN) was increased, and the connectivities between the mPFC and the anterior insular and middle frontal gyrus (key nodes of the SN) were also increased. The mPFC-left MTG connectivity was negatively correlated with the withdrawal symptom score. CONCLUSION: Long-term MMT enhanced the connectivity within the DMN which might be related to reduced withdrawal symptoms, and that between the DMN and SN which might be related to increase in salience values of heroin cues in individuals with HUD. Long-term MMT may be a double-edged sword in treatment for HUD.
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spelling pubmed-101497092023-05-02 Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study Chen, Jiajie Li, Yongbin Wang, Shu Li, Wei Liu, Yan Jin, Long Li, Zhe Zhu, Jia Wang, Fan Liu, Wei Xue, Jiuhua Shi, Hong Wang, Wei Jin, Chenwang Li, Qiang Front Psychiatry Psychiatry BACKGROUND: Methadone maintenance treatment (MMT) is a common treatment for heroin use disorder (HUD). Although individuals with HUD have been reported to show impaired coupling among the salience network (SN), executive control network (ECN), and default mode network (DMN), the effects of MMT on the coupling among three large-scale networks in individuals with HUD remains unclear. METHODS: Thirty-seven individuals with HUD undergoing MMT and 57 healthy controls were recruited. The longitudinal one-year follow-up study aimed to evaluate the effects of methadone on anxiety, depression, withdrawal symptoms and craving and number of relapse, and brain function (SN, DMN and bilateral ECN) in relation to heroin dependence. The changes in psychological characteristics and the coupling among large-scale networks after 1 year of MMT were analyzed. The associations between the changes in coupling among large-scale networks and psychological characteristics and the methadone dose were also examined. RESULTS: After 1 year of MMT, individuals with HUD showed a reduction in the withdrawal symptom score. The number of relapses was negatively correlated with the methadone dose over 1 year. The functional connectivity between the medial prefrontal cortex (mPFC) and the left middle temporal gyrus (MTG; both key nodes of the DMN) was increased, and the connectivities between the mPFC and the anterior insular and middle frontal gyrus (key nodes of the SN) were also increased. The mPFC-left MTG connectivity was negatively correlated with the withdrawal symptom score. CONCLUSION: Long-term MMT enhanced the connectivity within the DMN which might be related to reduced withdrawal symptoms, and that between the DMN and SN which might be related to increase in salience values of heroin cues in individuals with HUD. Long-term MMT may be a double-edged sword in treatment for HUD. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149709/ /pubmed/37139328 http://dx.doi.org/10.3389/fpsyt.2023.1132407 Text en Copyright © 2023 Chen, Li, Wang, Li, Liu, Jin, Li, Zhu, Wang, Liu, Xue, Shi, Wang, Jin and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Chen, Jiajie
Li, Yongbin
Wang, Shu
Li, Wei
Liu, Yan
Jin, Long
Li, Zhe
Zhu, Jia
Wang, Fan
Liu, Wei
Xue, Jiuhua
Shi, Hong
Wang, Wei
Jin, Chenwang
Li, Qiang
Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study
title Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study
title_full Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study
title_fullStr Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study
title_full_unstemmed Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study
title_short Methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: A longitudinal self-controlled resting-state fMRI study
title_sort methadone maintenance treatment alters couplings of default mode and salience networks in individuals with heroin use disorder: a longitudinal self-controlled resting-state fmri study
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149709/
https://www.ncbi.nlm.nih.gov/pubmed/37139328
http://dx.doi.org/10.3389/fpsyt.2023.1132407
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