Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine

INTRODUCTION: Vaccine-induced myocarditis is a rare complication of messenger RNA (mRNA) COVID-19 vaccines. CASE PRESENTATION: We report a case of acute myopericarditis in a recipient of allogeneic hematopoietic cells following the first dose of the mRNA-1273 vaccine and the successful administratio...

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Autores principales: Valore, Luca, Junker, Till, Heilmann, Eva, Zuern, Christine S., Streif, Matthias, Drexler, Beatrice, Arranto, Christian, Halter, Jörg P., Berger, Christoph T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149711/
https://www.ncbi.nlm.nih.gov/pubmed/37139123
http://dx.doi.org/10.3389/fcvm.2023.1135848
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author Valore, Luca
Junker, Till
Heilmann, Eva
Zuern, Christine S.
Streif, Matthias
Drexler, Beatrice
Arranto, Christian
Halter, Jörg P.
Berger, Christoph T.
author_facet Valore, Luca
Junker, Till
Heilmann, Eva
Zuern, Christine S.
Streif, Matthias
Drexler, Beatrice
Arranto, Christian
Halter, Jörg P.
Berger, Christoph T.
author_sort Valore, Luca
collection PubMed
description INTRODUCTION: Vaccine-induced myocarditis is a rare complication of messenger RNA (mRNA) COVID-19 vaccines. CASE PRESENTATION: We report a case of acute myopericarditis in a recipient of allogeneic hematopoietic cells following the first dose of the mRNA-1273 vaccine and the successful administration of a second and third dose while on prophylactic treatment with colchicine to successfully complete the vaccination. CONCLUSION: Treatment and prevention of mRNA-vaccine-induced myopericarditis represent a clinical challenge. The use of colchicine is feasible and safe to potentially reduce the risk of this rare but severe complication and allows re-exposure to an mRNA vaccine.
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spelling pubmed-101497112023-05-02 Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine Valore, Luca Junker, Till Heilmann, Eva Zuern, Christine S. Streif, Matthias Drexler, Beatrice Arranto, Christian Halter, Jörg P. Berger, Christoph T. Front Cardiovasc Med Cardiovascular Medicine INTRODUCTION: Vaccine-induced myocarditis is a rare complication of messenger RNA (mRNA) COVID-19 vaccines. CASE PRESENTATION: We report a case of acute myopericarditis in a recipient of allogeneic hematopoietic cells following the first dose of the mRNA-1273 vaccine and the successful administration of a second and third dose while on prophylactic treatment with colchicine to successfully complete the vaccination. CONCLUSION: Treatment and prevention of mRNA-vaccine-induced myopericarditis represent a clinical challenge. The use of colchicine is feasible and safe to potentially reduce the risk of this rare but severe complication and allows re-exposure to an mRNA vaccine. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149711/ /pubmed/37139123 http://dx.doi.org/10.3389/fcvm.2023.1135848 Text en © 2023 Valore, Junker, Heilmann, Zuern, Streif, Drexler, Arranto, Halter and Berger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Valore, Luca
Junker, Till
Heilmann, Eva
Zuern, Christine S.
Streif, Matthias
Drexler, Beatrice
Arranto, Christian
Halter, Jörg P.
Berger, Christoph T.
Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine
title Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine
title_full Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine
title_fullStr Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine
title_full_unstemmed Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine
title_short Case report: mRNA-1273 COVID-19 vaccine-associated myopericarditis: Successful treatment and re-exposure with colchicine
title_sort case report: mrna-1273 covid-19 vaccine-associated myopericarditis: successful treatment and re-exposure with colchicine
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149711/
https://www.ncbi.nlm.nih.gov/pubmed/37139123
http://dx.doi.org/10.3389/fcvm.2023.1135848
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