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Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights

Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%–60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximat...

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Autores principales: Scarini, João Figueira, de Lima-Souza, Reydson Alcides, Lavareze, Luccas, Ribeiro de Assis, Maria Clara Falcão, Damas, Ingrid Iara, Altemani, Albina, Egal, Erika Said Abu, dos Santos, Jean Nunes, Bello, Ibrahim Olajide, Mariano, Fernanda Viviane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149834/
https://www.ncbi.nlm.nih.gov/pubmed/37138857
http://dx.doi.org/10.3389/froh.2023.942604
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author Scarini, João Figueira
de Lima-Souza, Reydson Alcides
Lavareze, Luccas
Ribeiro de Assis, Maria Clara Falcão
Damas, Ingrid Iara
Altemani, Albina
Egal, Erika Said Abu
dos Santos, Jean Nunes
Bello, Ibrahim Olajide
Mariano, Fernanda Viviane
author_facet Scarini, João Figueira
de Lima-Souza, Reydson Alcides
Lavareze, Luccas
Ribeiro de Assis, Maria Clara Falcão
Damas, Ingrid Iara
Altemani, Albina
Egal, Erika Said Abu
dos Santos, Jean Nunes
Bello, Ibrahim Olajide
Mariano, Fernanda Viviane
author_sort Scarini, João Figueira
collection PubMed
description Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%–60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%–6% of all salivary gland tumors. Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression. The extracellular matrix (ECM) comprises a heterogeneous and versatile network of macromolecules synthesized and secreted by embryonic cells. In the PA-CXPA sequence, ECM is formed by a variety of components including collagen, elastin, fibronectin, laminins, glycosaminoglycans, proteoglycans, and other glycoproteins, mainly secreted by epithelial cells, myoepithelial cells, cancer-associated fibroblasts, immune cells, and endothelial cells. Like in other tumors including breast cancer, ECM changes play an important role in the PA-CXPA sequence. This review summarizes what is currently known about the role of ECM during CXPA development.
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spelling pubmed-101498342023-05-02 Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights Scarini, João Figueira de Lima-Souza, Reydson Alcides Lavareze, Luccas Ribeiro de Assis, Maria Clara Falcão Damas, Ingrid Iara Altemani, Albina Egal, Erika Said Abu dos Santos, Jean Nunes Bello, Ibrahim Olajide Mariano, Fernanda Viviane Front Oral Health Oral Health Pleomorphic adenoma (PA) is the most common salivary gland tumor, accounting for 50%–60% of these neoplasms. If untreated, 6.2% of PA may undergo malignant transformation to carcinoma ex-pleomorphic adenoma (CXPA). CXPA is a rare and aggressive malignant tumor, whose prevalence represents approximately 3%–6% of all salivary gland tumors. Although the pathogenesis of the PA-CXPA transition remains unclear, CXPA development requires the participation of cellular components and the tumor microenvironment for its progression. The extracellular matrix (ECM) comprises a heterogeneous and versatile network of macromolecules synthesized and secreted by embryonic cells. In the PA-CXPA sequence, ECM is formed by a variety of components including collagen, elastin, fibronectin, laminins, glycosaminoglycans, proteoglycans, and other glycoproteins, mainly secreted by epithelial cells, myoepithelial cells, cancer-associated fibroblasts, immune cells, and endothelial cells. Like in other tumors including breast cancer, ECM changes play an important role in the PA-CXPA sequence. This review summarizes what is currently known about the role of ECM during CXPA development. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149834/ /pubmed/37138857 http://dx.doi.org/10.3389/froh.2023.942604 Text en © 2023 Scarini, de Lima-Souza, Lavareze, Ribeiro de Assis, Damas, Altemani, Egal, dos Santos, Bello and Mariano. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oral Health
Scarini, João Figueira
de Lima-Souza, Reydson Alcides
Lavareze, Luccas
Ribeiro de Assis, Maria Clara Falcão
Damas, Ingrid Iara
Altemani, Albina
Egal, Erika Said Abu
dos Santos, Jean Nunes
Bello, Ibrahim Olajide
Mariano, Fernanda Viviane
Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
title Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
title_full Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
title_fullStr Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
title_full_unstemmed Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
title_short Heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
title_sort heterogeneity and versatility of the extracellular matrix during the transition from pleomorphic adenoma to carcinoma ex pleomorphic adenoma: cumulative findings from basic research and new insights
topic Oral Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149834/
https://www.ncbi.nlm.nih.gov/pubmed/37138857
http://dx.doi.org/10.3389/froh.2023.942604
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