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Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion

Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR). PCs contain active biomolecules such as cytokines and lipid mediators. The proces...

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Autores principales: Duchez, Anne-Claire, Fauteux-Daniel, Sébastien, Sut, Caroline, Ebermeyer, Theo, Heestermans, Marco, Arthaud, Charles-Antoine, Eyraud, Marie-Ange, Prier, Amélie, Audoux, Estelle, Bertrand-Michel, Justine, Payrastre, Bernard, Garraud, Olivier, Boilard, Eric, Hamzeh-Cognasse, Hind, Cognasse, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149858/
https://www.ncbi.nlm.nih.gov/pubmed/37138863
http://dx.doi.org/10.3389/fimmu.2023.1031968
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author Duchez, Anne-Claire
Fauteux-Daniel, Sébastien
Sut, Caroline
Ebermeyer, Theo
Heestermans, Marco
Arthaud, Charles-Antoine
Eyraud, Marie-Ange
Prier, Amélie
Audoux, Estelle
Bertrand-Michel, Justine
Payrastre, Bernard
Garraud, Olivier
Boilard, Eric
Hamzeh-Cognasse, Hind
Cognasse, Fabrice
author_facet Duchez, Anne-Claire
Fauteux-Daniel, Sébastien
Sut, Caroline
Ebermeyer, Theo
Heestermans, Marco
Arthaud, Charles-Antoine
Eyraud, Marie-Ange
Prier, Amélie
Audoux, Estelle
Bertrand-Michel, Justine
Payrastre, Bernard
Garraud, Olivier
Boilard, Eric
Hamzeh-Cognasse, Hind
Cognasse, Fabrice
author_sort Duchez, Anne-Claire
collection PubMed
description Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR). PCs contain active biomolecules such as cytokines and lipid mediators. The processing and storage of PCs creates so-called structural and biochemical storage lesions that accumulate when blood products reach their shelf life. We sought to investigate lipid mediators as bioactive molecules of interest during storage and review associations with adverse reactions post-transfusion. To facilitate understanding, we focused on single donor apheresis (SDA) PCs with approximately 31.8% of PCs being delivered in our setting. Indeed, pooled PCs are the most widely transfused products, but the study of a single donor lipid mediator is easier to interpret. We are investigating key lipid mediators involved in AR. Adverse reactions were closely monitored in accordance with current national and regional haemovigilance protocols. Residual PCs were analysed post-transfusion in a series of observations, both with and without severe reactions in recipients. A decrease in the lysophosphatidylcholine species to produce the lysophosphatidic acid species has been observed during storage and in the case of AR. Lysophosphatidic acid increased with primarily platelet-inhibitor lipids. Anti-inflammatory platelet-induced inhibition lipids were weakly expressed in cases of severe adverse reactions. We therefore propose that a decrease in lysophosphatidylcholine and an increase in lysophosphatidic acid can prospectively predict serious adverse transfusion reactions.
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spelling pubmed-101498582023-05-02 Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion Duchez, Anne-Claire Fauteux-Daniel, Sébastien Sut, Caroline Ebermeyer, Theo Heestermans, Marco Arthaud, Charles-Antoine Eyraud, Marie-Ange Prier, Amélie Audoux, Estelle Bertrand-Michel, Justine Payrastre, Bernard Garraud, Olivier Boilard, Eric Hamzeh-Cognasse, Hind Cognasse, Fabrice Front Immunol Immunology Platelet concentrate (PC) transfusion seeks to provide haemostasis in patients presenting severe central thrombocytopenia or severe bleeding. PCs may induce adverse reactions (AR) that can occasionally be severe (SAR). PCs contain active biomolecules such as cytokines and lipid mediators. The processing and storage of PCs creates so-called structural and biochemical storage lesions that accumulate when blood products reach their shelf life. We sought to investigate lipid mediators as bioactive molecules of interest during storage and review associations with adverse reactions post-transfusion. To facilitate understanding, we focused on single donor apheresis (SDA) PCs with approximately 31.8% of PCs being delivered in our setting. Indeed, pooled PCs are the most widely transfused products, but the study of a single donor lipid mediator is easier to interpret. We are investigating key lipid mediators involved in AR. Adverse reactions were closely monitored in accordance with current national and regional haemovigilance protocols. Residual PCs were analysed post-transfusion in a series of observations, both with and without severe reactions in recipients. A decrease in the lysophosphatidylcholine species to produce the lysophosphatidic acid species has been observed during storage and in the case of AR. Lysophosphatidic acid increased with primarily platelet-inhibitor lipids. Anti-inflammatory platelet-induced inhibition lipids were weakly expressed in cases of severe adverse reactions. We therefore propose that a decrease in lysophosphatidylcholine and an increase in lysophosphatidic acid can prospectively predict serious adverse transfusion reactions. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149858/ /pubmed/37138863 http://dx.doi.org/10.3389/fimmu.2023.1031968 Text en Copyright © 2023 Duchez, Fauteux-Daniel, Sut, Ebermeyer, Heestermans, Arthaud, Eyraud, Prier, Audoux, Bertrand-Michel, Payrastre, Garraud, Boilard, Hamzeh-Cognasse and Cognasse https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Duchez, Anne-Claire
Fauteux-Daniel, Sébastien
Sut, Caroline
Ebermeyer, Theo
Heestermans, Marco
Arthaud, Charles-Antoine
Eyraud, Marie-Ange
Prier, Amélie
Audoux, Estelle
Bertrand-Michel, Justine
Payrastre, Bernard
Garraud, Olivier
Boilard, Eric
Hamzeh-Cognasse, Hind
Cognasse, Fabrice
Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
title Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
title_full Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
title_fullStr Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
title_full_unstemmed Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
title_short Bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
title_sort bioactive lipids as biomarkers of adverse reactions associated with apheresis platelet concentrate transfusion
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149858/
https://www.ncbi.nlm.nih.gov/pubmed/37138863
http://dx.doi.org/10.3389/fimmu.2023.1031968
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