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Diabetes mellitus in peripheral artery disease: Beyond a risk factor

Peripheral artery disease (PAD) is one of the major cardiovascular diseases that afflicts a large population worldwide. PAD results from occlusion of the peripheral arteries of the lower extremities. Although diabetes is a major risk factor for developing PAD, coexistence of PAD and diabetes poses s...

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Autores principales: Singh, Madhu V., Dokun, Ayotunde O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149861/
https://www.ncbi.nlm.nih.gov/pubmed/37139134
http://dx.doi.org/10.3389/fcvm.2023.1148040
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author Singh, Madhu V.
Dokun, Ayotunde O.
author_facet Singh, Madhu V.
Dokun, Ayotunde O.
author_sort Singh, Madhu V.
collection PubMed
description Peripheral artery disease (PAD) is one of the major cardiovascular diseases that afflicts a large population worldwide. PAD results from occlusion of the peripheral arteries of the lower extremities. Although diabetes is a major risk factor for developing PAD, coexistence of PAD and diabetes poses significantly greater risk of developing critical limb threatening ischemia (CLTI) with poor prognosis for limb amputation and high mortality. Despite the prevalence of PAD, there are no effective therapeutic interventions as the molecular mechanism of how diabetes worsens PAD is not understood. With increasing cases of diabetes worldwide, the risk of complications in PAD have greatly increased. PAD and diabetes affect a complex web of multiple cellular, biochemical and molecular pathways. Therefore, it is important to understand the molecular components that can be targeted for therapeutic purposes. In this review, we describe some major developments in enhancing the understanding of the interactions of PAD and diabetes. We also provide results from our laboratory in this context.
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spelling pubmed-101498612023-05-02 Diabetes mellitus in peripheral artery disease: Beyond a risk factor Singh, Madhu V. Dokun, Ayotunde O. Front Cardiovasc Med Cardiovascular Medicine Peripheral artery disease (PAD) is one of the major cardiovascular diseases that afflicts a large population worldwide. PAD results from occlusion of the peripheral arteries of the lower extremities. Although diabetes is a major risk factor for developing PAD, coexistence of PAD and diabetes poses significantly greater risk of developing critical limb threatening ischemia (CLTI) with poor prognosis for limb amputation and high mortality. Despite the prevalence of PAD, there are no effective therapeutic interventions as the molecular mechanism of how diabetes worsens PAD is not understood. With increasing cases of diabetes worldwide, the risk of complications in PAD have greatly increased. PAD and diabetes affect a complex web of multiple cellular, biochemical and molecular pathways. Therefore, it is important to understand the molecular components that can be targeted for therapeutic purposes. In this review, we describe some major developments in enhancing the understanding of the interactions of PAD and diabetes. We also provide results from our laboratory in this context. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149861/ /pubmed/37139134 http://dx.doi.org/10.3389/fcvm.2023.1148040 Text en © 2023 Singh and Dokun. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Singh, Madhu V.
Dokun, Ayotunde O.
Diabetes mellitus in peripheral artery disease: Beyond a risk factor
title Diabetes mellitus in peripheral artery disease: Beyond a risk factor
title_full Diabetes mellitus in peripheral artery disease: Beyond a risk factor
title_fullStr Diabetes mellitus in peripheral artery disease: Beyond a risk factor
title_full_unstemmed Diabetes mellitus in peripheral artery disease: Beyond a risk factor
title_short Diabetes mellitus in peripheral artery disease: Beyond a risk factor
title_sort diabetes mellitus in peripheral artery disease: beyond a risk factor
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149861/
https://www.ncbi.nlm.nih.gov/pubmed/37139134
http://dx.doi.org/10.3389/fcvm.2023.1148040
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