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Understanding CD4(+) T cells in autoimmune bullous diseases

Autoimmune bullous diseases (AIBDs) are a group of life-threatening blistering diseases caused by autoantibodies that target proteins in the skin and mucosa. Autoantibodies are the most important mediator in the pathogenesis of AIBDs, and various immune mechanisms contribute to the production of the...

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Autores principales: Lee, A Yeong, Kim, Taehee, Kim, Jong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149917/
https://www.ncbi.nlm.nih.gov/pubmed/37138879
http://dx.doi.org/10.3389/fimmu.2023.1161927
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author Lee, A Yeong
Kim, Taehee
Kim, Jong Hoon
author_facet Lee, A Yeong
Kim, Taehee
Kim, Jong Hoon
author_sort Lee, A Yeong
collection PubMed
description Autoimmune bullous diseases (AIBDs) are a group of life-threatening blistering diseases caused by autoantibodies that target proteins in the skin and mucosa. Autoantibodies are the most important mediator in the pathogenesis of AIBDs, and various immune mechanisms contribute to the production of these pathogenic autoantibodies. Recently, significant progress has been made in understanding how CD4(+) T cells drive autoantibody production in these diseases. Here, we review the critical role of CD4(+) T cells in the production of pathogenic autoantibodies for the initiation and perpetuation of humoral response in AIBDs. To gain an in-depth understanding of CD4(+) T-cell pathogenicity, antigen specificity, and mechanisms of immune tolerance, this review covers comprehensive mouse and human studies of pemphigus and bullous pemphigoid. Further exploration of pathogenic CD4(+) T cells will potentially provide immune targets for improved treatment of AIBDs.
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spelling pubmed-101499172023-05-02 Understanding CD4(+) T cells in autoimmune bullous diseases Lee, A Yeong Kim, Taehee Kim, Jong Hoon Front Immunol Immunology Autoimmune bullous diseases (AIBDs) are a group of life-threatening blistering diseases caused by autoantibodies that target proteins in the skin and mucosa. Autoantibodies are the most important mediator in the pathogenesis of AIBDs, and various immune mechanisms contribute to the production of these pathogenic autoantibodies. Recently, significant progress has been made in understanding how CD4(+) T cells drive autoantibody production in these diseases. Here, we review the critical role of CD4(+) T cells in the production of pathogenic autoantibodies for the initiation and perpetuation of humoral response in AIBDs. To gain an in-depth understanding of CD4(+) T-cell pathogenicity, antigen specificity, and mechanisms of immune tolerance, this review covers comprehensive mouse and human studies of pemphigus and bullous pemphigoid. Further exploration of pathogenic CD4(+) T cells will potentially provide immune targets for improved treatment of AIBDs. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10149917/ /pubmed/37138879 http://dx.doi.org/10.3389/fimmu.2023.1161927 Text en Copyright © 2023 Lee, Kim and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Lee, A Yeong
Kim, Taehee
Kim, Jong Hoon
Understanding CD4(+) T cells in autoimmune bullous diseases
title Understanding CD4(+) T cells in autoimmune bullous diseases
title_full Understanding CD4(+) T cells in autoimmune bullous diseases
title_fullStr Understanding CD4(+) T cells in autoimmune bullous diseases
title_full_unstemmed Understanding CD4(+) T cells in autoimmune bullous diseases
title_short Understanding CD4(+) T cells in autoimmune bullous diseases
title_sort understanding cd4(+) t cells in autoimmune bullous diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10149917/
https://www.ncbi.nlm.nih.gov/pubmed/37138879
http://dx.doi.org/10.3389/fimmu.2023.1161927
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