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(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study

BACKGROUND: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve...

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Autores principales: Faria, Murilo Henrique, Simieli, Lucas, Rietdyk, Shirley, Penedo, Tiago, Santinelli, Felipe Balistieri, Barbieri, Fabio Augusto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150081/
https://www.ncbi.nlm.nih.gov/pubmed/37139089
http://dx.doi.org/10.3389/fnagi.2023.1142540
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author Faria, Murilo Henrique
Simieli, Lucas
Rietdyk, Shirley
Penedo, Tiago
Santinelli, Felipe Balistieri
Barbieri, Fabio Augusto
author_facet Faria, Murilo Henrique
Simieli, Lucas
Rietdyk, Shirley
Penedo, Tiago
Santinelli, Felipe Balistieri
Barbieri, Fabio Augusto
author_sort Faria, Murilo Henrique
collection PubMed
description BACKGROUND: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. OBJECTIVE: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. METHODS: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. RESULTS: Parkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively. CONCLUSION: Parkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD.
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spelling pubmed-101500812023-05-02 (A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study Faria, Murilo Henrique Simieli, Lucas Rietdyk, Shirley Penedo, Tiago Santinelli, Felipe Balistieri Barbieri, Fabio Augusto Front Aging Neurosci Aging Neuroscience BACKGROUND: Gait asymmetry and deficits in gait initiation (GI) are among the most disabling symptoms in people with Parkinson’s disease (PwPD). Understanding if PwPD with reduced asymmetry during GI have higher asymmetry in cortical activity may provide support for an adaptive mechanism to improve GI, particularly in the presence of an obstacle. OBJECTIVE: This study quantified the asymmetry of anticipatory postural adjustments (APAs), stepping parameters and cortical activity during GI, and tested if the presence of an obstacle regulates asymmetry in PwPD. METHODS: Sixteen PwPD and 16 control group (CG) performed 20-trials in two conditions: unobstructed and obstructed GI with right and left limbs. We measured, through symmetry index, (i) motor parameters: APAs and stepping, and (ii) cortical activity: the PSD of the frontal, sensorimotor and occipital areas during APA, STEP-I (moment of heel-off of the leading foot in the GI until the heel contact of the same foot); and STEP-II (moment of the heel-off of the trailing foot in the GI until the heel contact of the same foot) phases. RESULTS: Parkinson’s disease showed higher asymmetry in cortical activity during APA, STEP-I and STEP-II phases and step velocity (STEP-II phase) during unobstructed GI than CG. However, unexpectedly, PwPD reduced the level of asymmetry of anterior–posterior displacement (p < 0.01) and medial-lateral velocity (p < 0.05) of the APAs. Also, when an obstacle was in place, PwPD showed higher APAs asymmetry (medial-lateral velocity: p < 0.002), with reduced and increased asymmetry of the cortical activity during APA and STEP-I phases, respectively. CONCLUSION: Parkinson’s disease were not motor asymmetric during GI, indicating that higher cortical activity asymmetry can be interpreted as an adaptive behavior to reduce motor asymmetry. In addition, the presence of obstacle did not regulate motor asymmetry during GI in PwPD. Frontiers Media S.A. 2023-04-17 /pmc/articles/PMC10150081/ /pubmed/37139089 http://dx.doi.org/10.3389/fnagi.2023.1142540 Text en Copyright © 2023 Faria, Simieli, Rietdyk, Penedo, Santinelli and Barbieri. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Faria, Murilo Henrique
Simieli, Lucas
Rietdyk, Shirley
Penedo, Tiago
Santinelli, Felipe Balistieri
Barbieri, Fabio Augusto
(A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
title (A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
title_full (A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
title_fullStr (A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
title_full_unstemmed (A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
title_short (A)symmetry during gait initiation in people with Parkinson’s disease: A motor and cortical activity exploratory study
title_sort (a)symmetry during gait initiation in people with parkinson’s disease: a motor and cortical activity exploratory study
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150081/
https://www.ncbi.nlm.nih.gov/pubmed/37139089
http://dx.doi.org/10.3389/fnagi.2023.1142540
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