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Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021

The population in rural southwest Alaska has been disproportionately affected by COVID-19. To assess the benefit of COVID-19 vaccines, we analyzed data from the regional health system. We estimated vaccine effectiveness (VE) during January 16–December 3, 2021, against symptomatic SARS-CoV-2 infectio...

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Autores principales: Lefferts, Brian, Bruden, Dana, Plumb, Ian D., Hodges, Ellen, Bates, Elizabeth, January, Gerald, Bruce, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150184/
https://www.ncbi.nlm.nih.gov/pubmed/37150620
http://dx.doi.org/10.1016/j.vaccine.2023.04.070
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author Lefferts, Brian
Bruden, Dana
Plumb, Ian D.
Hodges, Ellen
Bates, Elizabeth
January, Gerald
Bruce, Michael G.
author_facet Lefferts, Brian
Bruden, Dana
Plumb, Ian D.
Hodges, Ellen
Bates, Elizabeth
January, Gerald
Bruce, Michael G.
author_sort Lefferts, Brian
collection PubMed
description The population in rural southwest Alaska has been disproportionately affected by COVID-19. To assess the benefit of COVID-19 vaccines, we analyzed data from the regional health system. We estimated vaccine effectiveness (VE) during January 16–December 3, 2021, against symptomatic SARS-CoV-2 infection after a primary series or booster dose, and overall VE against hospitalization. VE of a primary series against symptomatic infection among adult residents was 91.3% (95% CI: 85.7, 95.2) during January 16–May 7, 2021, 50.3% (95% CI, 41.1%–58.8%) during July 17–September 24, and 37.0% (95% CI, 27.8–45.0) during September 25–December 3, 2021; VE of a booster dose during September 25–December 3, 2021, was 92.1% (95% CI: 87.2–95.2). During the overall study period, VE against hospitalization was 91.9% (95% CI: 85.4–95.5). COVID-19 vaccination offered strong protection against hospitalization and a booster dose restored protection against symptomatic infection.
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spelling pubmed-101501842023-05-01 Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021 Lefferts, Brian Bruden, Dana Plumb, Ian D. Hodges, Ellen Bates, Elizabeth January, Gerald Bruce, Michael G. Vaccine Article The population in rural southwest Alaska has been disproportionately affected by COVID-19. To assess the benefit of COVID-19 vaccines, we analyzed data from the regional health system. We estimated vaccine effectiveness (VE) during January 16–December 3, 2021, against symptomatic SARS-CoV-2 infection after a primary series or booster dose, and overall VE against hospitalization. VE of a primary series against symptomatic infection among adult residents was 91.3% (95% CI: 85.7, 95.2) during January 16–May 7, 2021, 50.3% (95% CI, 41.1%–58.8%) during July 17–September 24, and 37.0% (95% CI, 27.8–45.0) during September 25–December 3, 2021; VE of a booster dose during September 25–December 3, 2021, was 92.1% (95% CI: 87.2–95.2). During the overall study period, VE against hospitalization was 91.9% (95% CI: 85.4–95.5). COVID-19 vaccination offered strong protection against hospitalization and a booster dose restored protection against symptomatic infection. Elsevier Science 2023-05-26 2023-05-01 /pmc/articles/PMC10150184/ /pubmed/37150620 http://dx.doi.org/10.1016/j.vaccine.2023.04.070 Text en Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lefferts, Brian
Bruden, Dana
Plumb, Ian D.
Hodges, Ellen
Bates, Elizabeth
January, Gerald
Bruce, Michael G.
Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021
title Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021
title_full Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021
title_fullStr Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021
title_full_unstemmed Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021
title_short Effectiveness of the COVID-19 vaccines on preventing symptomatic SARS-CoV-2 infections and hospitalizations in Southwestern Alaska, January–December 2021
title_sort effectiveness of the covid-19 vaccines on preventing symptomatic sars-cov-2 infections and hospitalizations in southwestern alaska, january–december 2021
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150184/
https://www.ncbi.nlm.nih.gov/pubmed/37150620
http://dx.doi.org/10.1016/j.vaccine.2023.04.070
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