Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models

Previous studies have linked dysfunctional I(to) arising from mutations to KCND3-encoded Kv4.3 and KCND2-encoded Kv4.2 to atrial fibrillation. Using computational models, this study aimed to investigate the mechanisms underlying pro-arrhythmic effects of the gain-of-function Kv4.3 (T361S, A545P) and...

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Detalles Bibliográficos
Autores principales: Alrabghi, Ghadah, Liu, Yizhou, Hu, Wei, Hancox, Jules C., Zhang, Henggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Part II: Cardiomyocyte Surface Membrane Recovery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150223/
https://www.ncbi.nlm.nih.gov/pubmed/37122220
http://dx.doi.org/10.1098/rstb.2022.0166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150223/
https://www.ncbi.nlm.nih.gov/pubmed/37122220
http://dx.doi.org/10.1098/rstb.2022.0166

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