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Human atrial fibrillation and genetic defects in transient outward currents: mechanistic insights from multi-scale computational models

Previous studies have linked dysfunctional I(to) arising from mutations to KCND3-encoded Kv4.3 and KCND2-encoded Kv4.2 to atrial fibrillation. Using computational models, this study aimed to investigate the mechanisms underlying pro-arrhythmic effects of the gain-of-function Kv4.3 (T361S, A545P) and...

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Detalles Bibliográficos
Autores principales:	Alrabghi, Ghadah, Liu, Yizhou, Hu, Wei, Hancox, Jules C., Zhang, Henggui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2023
Materias:	Part II: Cardiomyocyte Surface Membrane Recovery
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150223/ https://www.ncbi.nlm.nih.gov/pubmed/37122220 http://dx.doi.org/10.1098/rstb.2022.0166

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