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Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow()
Velocity-selective inversion (VSI) based velocity-selective arterial spin labeling (VSASL) has been developed to measure cerebral blood flow (CBF) with low susceptibility to the prolonged arterial transit time and high sensitivity to brain perfusion signal. The purpose of this magnetic resonance ima...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150252/ https://www.ncbi.nlm.nih.gov/pubmed/36931331 http://dx.doi.org/10.1016/j.neuroimage.2023.120039 |
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author | Xu, Feng Liu, Dapeng Zhu, Dan Hillis, Argye E. Bakker, Arnold Soldan, Anja Albert, Marilyn S. Lin, Doris D.M. Qin, Qin |
author_facet | Xu, Feng Liu, Dapeng Zhu, Dan Hillis, Argye E. Bakker, Arnold Soldan, Anja Albert, Marilyn S. Lin, Doris D.M. Qin, Qin |
author_sort | Xu, Feng |
collection | PubMed |
description | Velocity-selective inversion (VSI) based velocity-selective arterial spin labeling (VSASL) has been developed to measure cerebral blood flow (CBF) with low susceptibility to the prolonged arterial transit time and high sensitivity to brain perfusion signal. The purpose of this magnetic resonance imaging study is to evaluate the test-retest reliability of a VSI-prepared 3D VSASL protocol with whole-brain coverage to detect baseline CBF variations among cognitively normal participants in different brain regions. Coefficients of variation (CoV) of both absolute and relative CBF across scans or sessions, subjects, and gray matter regions were calculated, and corresponding intraclass correlation coefficients (ICC) were computed. The higher between-subject CoV of absolute CBF (13.4±2.0%) over within-subject CoV (within-session: 3.8±1.1%; between-session: 4.9±0.9%) yielded moderate to excellent ICC (within-session: 0.88±0.08; between-session: 0.77±0.14) to detect normal variations of individual CBF. The higher between-region CoV of relative CBF (11.4±3.0%) over within-region CoV (within-session: 2.3±0.9%; between-session: 3.3±1.0%) yielded excellent ICC (within-session: 0.92±0.06; between-session: 0.85±0.12) to detect normal variations of regional CBF. Age, blood pressure, end-tidal CO(2), and hematocrit partially explained the variability of CBF across subjects. Together these results show excellent test-retest reliability of VSASL to detect both between-subject and between-region variations supporting its clinical utility. |
format | Online Article Text |
id | pubmed-10150252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
record_format | MEDLINE/PubMed |
spelling | pubmed-101502522023-05-01 Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() Xu, Feng Liu, Dapeng Zhu, Dan Hillis, Argye E. Bakker, Arnold Soldan, Anja Albert, Marilyn S. Lin, Doris D.M. Qin, Qin Neuroimage Article Velocity-selective inversion (VSI) based velocity-selective arterial spin labeling (VSASL) has been developed to measure cerebral blood flow (CBF) with low susceptibility to the prolonged arterial transit time and high sensitivity to brain perfusion signal. The purpose of this magnetic resonance imaging study is to evaluate the test-retest reliability of a VSI-prepared 3D VSASL protocol with whole-brain coverage to detect baseline CBF variations among cognitively normal participants in different brain regions. Coefficients of variation (CoV) of both absolute and relative CBF across scans or sessions, subjects, and gray matter regions were calculated, and corresponding intraclass correlation coefficients (ICC) were computed. The higher between-subject CoV of absolute CBF (13.4±2.0%) over within-subject CoV (within-session: 3.8±1.1%; between-session: 4.9±0.9%) yielded moderate to excellent ICC (within-session: 0.88±0.08; between-session: 0.77±0.14) to detect normal variations of individual CBF. The higher between-region CoV of relative CBF (11.4±3.0%) over within-region CoV (within-session: 2.3±0.9%; between-session: 3.3±1.0%) yielded excellent ICC (within-session: 0.92±0.06; between-session: 0.85±0.12) to detect normal variations of regional CBF. Age, blood pressure, end-tidal CO(2), and hematocrit partially explained the variability of CBF across subjects. Together these results show excellent test-retest reliability of VSASL to detect both between-subject and between-region variations supporting its clinical utility. 2023-05-01 2023-03-16 /pmc/articles/PMC10150252/ /pubmed/36931331 http://dx.doi.org/10.1016/j.neuroimage.2023.120039 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ) |
spellingShingle | Article Xu, Feng Liu, Dapeng Zhu, Dan Hillis, Argye E. Bakker, Arnold Soldan, Anja Albert, Marilyn S. Lin, Doris D.M. Qin, Qin Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
title | Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
title_full | Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
title_fullStr | Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
title_full_unstemmed | Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
title_short | Test-retest reliability of 3D velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
title_sort | test-retest reliability of 3d velocity-selective arterial spin labeling for detecting normal variations of cerebral blood flow() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150252/ https://www.ncbi.nlm.nih.gov/pubmed/36931331 http://dx.doi.org/10.1016/j.neuroimage.2023.120039 |
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