In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target

Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding proteins (RBP) selectively enriched in human AML...

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Detalles Bibliográficos
Autores principales: Vujovic, Ana, de Rooij, Laura, Chahi, Ava Keyvani, Chen, He Tian, Yee, Brian A., Loganathan, Sampath K., Liu, Lina, Chan, Derek C.H., Tajik, Amanda, Tsao, Emily, Moreira, Steven, Joshi, Pratik, Xu, Joshua, Wong, Nicholas, Balde, Zaldy, Jahangiri, Soheil, Zandi, Sasan, Aigner, Stefan, Dick, John E., Minden, Mark D., Schramek, Daniel, Yeo, Gene W., Hope, Kristin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150294/
https://www.ncbi.nlm.nih.gov/pubmed/36763002
http://dx.doi.org/10.1158/2643-3230.BCD-22-0086

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