Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles

BACKGROUND: Single-cell RNA sequencing (scRNA-seq) provides valuable insights into human islet cell types and their corresponding stable gene expression profiles. However, this approach requires cell dissociation that complicates its utility in vivo. On the other hand, single-nucleus RNA sequencing...

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Detalles Bibliográficos
Autores principales: Kang, Randy B., Li, Yansui, Rosselot, Carolina, Zhang, Tuo, Siddiq, Mustafa, Rajbhandari, Prashant, Stewart, Andrew F., Scott, Donald K., Garcia-Ocana, Adolfo, Lu, Geming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150516/
https://www.ncbi.nlm.nih.gov/pubmed/37127706
http://dx.doi.org/10.1186/s13073-023-01179-2

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