High-Contrast PET Imaging with [(18)F]NT160, a Class-IIa Histone Deacetylase Probe for In Vivo Imaging of Epigenetic Machinery in the Central Nervous System

[Image: see text] We utilized positron emission tomography (PET) imaging in vivo to map the spatiotemporal biodistribution/expression of class-IIa histone deacetylases (class-IIa HDACs) in the central nervous system (CNS). Herein we report an improved radiosynthesis of [(18)F]NT160 using 4-hydroxy-T...

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Detalles Bibliográficos
Autores principales: Turkman, Nashaat, Xu, Sulan, Huang, Chun-Han, Eyermann, Christopher, Salino, Julia, Khan, Palwasha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150721/
https://www.ncbi.nlm.nih.gov/pubmed/37068265
http://dx.doi.org/10.1021/acs.jmedchem.2c02064

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