Assessment of Pre-Clinical Liver Models Based on Their Ability to Predict the Liver-Tropism of Adeno-Associated Virus Vectors

The liver is a prime target for in vivo gene therapies using recombinant adeno-associated viral vectors. Multiple clinical trials have been undertaken for this target in the past 15 years; however, we are still to see market approval of the first liver-targeted adeno-associated virus (AAV)–based gen...

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Detalles Bibliográficos
Autores principales: Westhaus, Adrian, Cabanes-Creus, Marti, Dilworth, Kimberley L., Zhu, Erhua, Salas Gómez, David, Navarro, Renina G., Amaya, Anais K., Scott, Suzanne, Kwiatek, Magdalena, McCorkindale, Alexandra L., Hayman, Tara E., Frahm, Silke, Perocheau, Dany P., Tran, Bang Manh, Vincan, Elizabeth, Wong, Sharon L., Waters, Shafagh A., Riddiough, Georgina E., Perini, Marcos V., Wilson, Laurence O.W., Baruteau, Julien, Diecke, Sebastian, González-Aseguinolaza, Gloria, Santilli, Giorgia, Thrasher, Adrian J., Alexander, Ian E., Lisowski, Leszek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150726/
https://www.ncbi.nlm.nih.gov/pubmed/36927149
http://dx.doi.org/10.1089/hum.2022.188

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