Multiple Germline Events Contribute to Cancer Development in Patients with Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer-predisposition disorder. Approximately 70% of individuals who fit the clinical definition of LFS harbor a pathogenic germline variant in the TP53 tumor suppressor gene. However, the remaining 30% of patients lack a TP53 variant and even amon...

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Detalles Bibliográficos
Autores principales: Subasri, Vallijah, Light, Nicholas, Kanwar, Nisha, Brzezinski, Jack, Luo, Ping, Hansford, Jordan R., Cairney, Elizabeth, Portwine, Carol, Elser, Christine, Finlay, Jonathan L., Nichols, Kim E., Alon, Noa, Brunga, Ledia, Anson, Jo, Kohlmann, Wendy, de Andrade, Kelvin C., Khincha, Payal P., Savage, Sharon A., Schiffman, Joshua D., Weksberg, Rosanna, Pugh, Trevor J., Villani, Anita, Shlien, Adam, Goldenberg, Anna, Malkin, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150777/
https://www.ncbi.nlm.nih.gov/pubmed/37377903
http://dx.doi.org/10.1158/2767-9764.CRC-22-0402

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