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Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady

Carcinosarcoma of the breast is a subtype of metaplastic breast carcinoma characterized by differentiation of the neoplastic epithelium toward mesenchymal-looking elements. It is a highly aggressive rare subtype of invasive breast neoplasm that exhibits a distinct histologic entity. Only a limited n...

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Autores principales: Leng, Poh Nuan, Wan Zain, Wan Zainira, Mohammad Azmi, Mohd Azem Fathi, Yahya, Maya Mazuwin, Azis, Khairul Anuar, Mat Johar, Siti Fatimah Noor, Wan Sulaiman, Wan Azman, Balingi, Dumin, Tuan Sharif, Sharifah Emilia, Wan Abdul Rahman, Wan Faiziah, Chiew Chea, Lau, Haron, Juhara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150779/
https://www.ncbi.nlm.nih.gov/pubmed/37139022
http://dx.doi.org/10.7759/cureus.37003
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author Leng, Poh Nuan
Wan Zain, Wan Zainira
Mohammad Azmi, Mohd Azem Fathi
Yahya, Maya Mazuwin
Azis, Khairul Anuar
Mat Johar, Siti Fatimah Noor
Wan Sulaiman, Wan Azman
Balingi, Dumin
Tuan Sharif, Sharifah Emilia
Wan Abdul Rahman, Wan Faiziah
Chiew Chea, Lau
Haron, Juhara
author_facet Leng, Poh Nuan
Wan Zain, Wan Zainira
Mohammad Azmi, Mohd Azem Fathi
Yahya, Maya Mazuwin
Azis, Khairul Anuar
Mat Johar, Siti Fatimah Noor
Wan Sulaiman, Wan Azman
Balingi, Dumin
Tuan Sharif, Sharifah Emilia
Wan Abdul Rahman, Wan Faiziah
Chiew Chea, Lau
Haron, Juhara
author_sort Leng, Poh Nuan
collection PubMed
description Carcinosarcoma of the breast is a subtype of metaplastic breast carcinoma characterized by differentiation of the neoplastic epithelium toward mesenchymal-looking elements. It is a highly aggressive rare subtype of invasive breast neoplasm that exhibits a distinct histologic entity. Only a limited number of reports related to this type of disease have been reported. Here, we present a case of breast carcinosarcoma in a lady in her early 20s, which is relatively young among all cases published. It was challenging to achieve diagnosis preoperatively with histopathological evaluation of the ultrasound-guided tru-cut biopsy sample. With no evidence of distant metastasis clinically and radiologically, a surgical option was opted for. Left mastectomy and left chest wall reconstruction with deep inferior epigastric artery free flap were performed. Post-excision specimen was confirmed to be carcinosarcoma.
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spelling pubmed-101507792023-05-02 Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady Leng, Poh Nuan Wan Zain, Wan Zainira Mohammad Azmi, Mohd Azem Fathi Yahya, Maya Mazuwin Azis, Khairul Anuar Mat Johar, Siti Fatimah Noor Wan Sulaiman, Wan Azman Balingi, Dumin Tuan Sharif, Sharifah Emilia Wan Abdul Rahman, Wan Faiziah Chiew Chea, Lau Haron, Juhara Cureus Pathology Carcinosarcoma of the breast is a subtype of metaplastic breast carcinoma characterized by differentiation of the neoplastic epithelium toward mesenchymal-looking elements. It is a highly aggressive rare subtype of invasive breast neoplasm that exhibits a distinct histologic entity. Only a limited number of reports related to this type of disease have been reported. Here, we present a case of breast carcinosarcoma in a lady in her early 20s, which is relatively young among all cases published. It was challenging to achieve diagnosis preoperatively with histopathological evaluation of the ultrasound-guided tru-cut biopsy sample. With no evidence of distant metastasis clinically and radiologically, a surgical option was opted for. Left mastectomy and left chest wall reconstruction with deep inferior epigastric artery free flap were performed. Post-excision specimen was confirmed to be carcinosarcoma. Cureus 2023-04-01 /pmc/articles/PMC10150779/ /pubmed/37139022 http://dx.doi.org/10.7759/cureus.37003 Text en Copyright © 2023, Leng et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Leng, Poh Nuan
Wan Zain, Wan Zainira
Mohammad Azmi, Mohd Azem Fathi
Yahya, Maya Mazuwin
Azis, Khairul Anuar
Mat Johar, Siti Fatimah Noor
Wan Sulaiman, Wan Azman
Balingi, Dumin
Tuan Sharif, Sharifah Emilia
Wan Abdul Rahman, Wan Faiziah
Chiew Chea, Lau
Haron, Juhara
Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady
title Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady
title_full Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady
title_fullStr Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady
title_full_unstemmed Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady
title_short Carcinosarcoma: A Rare and Aggressive Breast Tumor in a Young Lady
title_sort carcinosarcoma: a rare and aggressive breast tumor in a young lady
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150779/
https://www.ncbi.nlm.nih.gov/pubmed/37139022
http://dx.doi.org/10.7759/cureus.37003
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