Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers

Long non-coding RNAs (lncRNAs) reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers. The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlat...

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Autores principales: Wang, Yuanyuan, Bai, Huihui, Jiang, Meina, Zhou, Chengwei, Gong, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150895/
https://www.ncbi.nlm.nih.gov/pubmed/37027401
http://dx.doi.org/10.1097/CM9.0000000000002392
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author Wang, Yuanyuan
Bai, Huihui
Jiang, Meina
Zhou, Chengwei
Gong, Zhaohui
author_facet Wang, Yuanyuan
Bai, Huihui
Jiang, Meina
Zhou, Chengwei
Gong, Zhaohui
author_sort Wang, Yuanyuan
collection PubMed
description Long non-coding RNAs (lncRNAs) reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers. The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlations in several cancers. Notably, JPX participates in cancer growth, metastasis, and chemoresistance, by acting as a competing endogenous RNA for microRNA, interacting with proteins, and regulating some specific signaling pathways. Moreover, JPX may serve as a potential biomarker and therapeutic target for the diagnosis, prognosis, and treatment of cancer. The present article summarizes our current understanding of the structure, expression, and function of JPX in malignant cancer processes and discusses its molecular mechanisms and potential applications in cancer biology and medicine.
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spelling pubmed-101508952023-05-02 Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers Wang, Yuanyuan Bai, Huihui Jiang, Meina Zhou, Chengwei Gong, Zhaohui Chin Med J (Engl) Review Articles Long non-coding RNAs (lncRNAs) reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers. The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlations in several cancers. Notably, JPX participates in cancer growth, metastasis, and chemoresistance, by acting as a competing endogenous RNA for microRNA, interacting with proteins, and regulating some specific signaling pathways. Moreover, JPX may serve as a potential biomarker and therapeutic target for the diagnosis, prognosis, and treatment of cancer. The present article summarizes our current understanding of the structure, expression, and function of JPX in malignant cancer processes and discusses its molecular mechanisms and potential applications in cancer biology and medicine. Lippincott Williams & Wilkins 2023-04-05 2023-03-28 /pmc/articles/PMC10150895/ /pubmed/37027401 http://dx.doi.org/10.1097/CM9.0000000000002392 Text en Copyright © 2023 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review Articles
Wang, Yuanyuan
Bai, Huihui
Jiang, Meina
Zhou, Chengwei
Gong, Zhaohui
Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers
title Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers
title_full Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers
title_fullStr Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers
title_full_unstemmed Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers
title_short Emerging role of long non-coding RNA JPX in malignant processes and potential applications in cancers
title_sort emerging role of long non-coding rna jpx in malignant processes and potential applications in cancers
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150895/
https://www.ncbi.nlm.nih.gov/pubmed/37027401
http://dx.doi.org/10.1097/CM9.0000000000002392
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