Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations

Acute myeloid leukemia (AML) is a complex and aggressive malignancy that occurs due to genetic mutations and subsequent stem cell overproduction. We report a case of a patient with AML and a highly fatal, uncommon TP53 mutation who developed dermatologic manifestations. This report serves to highlig...

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Detalles Bibliográficos
Autores principales: Lott, Ronald, Stawitzky, Sara, Stroia, Alexandra, Awad, Angela, Kam, Anthony, Bleicher, Maxim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150939/
https://www.ncbi.nlm.nih.gov/pubmed/37139024
http://dx.doi.org/10.7759/cureus.37012
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author Lott, Ronald
Stawitzky, Sara
Stroia, Alexandra
Awad, Angela
Kam, Anthony
Bleicher, Maxim
author_facet Lott, Ronald
Stawitzky, Sara
Stroia, Alexandra
Awad, Angela
Kam, Anthony
Bleicher, Maxim
author_sort Lott, Ronald
collection PubMed
description Acute myeloid leukemia (AML) is a complex and aggressive malignancy that occurs due to genetic mutations and subsequent stem cell overproduction. We report a case of a patient with AML and a highly fatal, uncommon TP53 mutation who developed dermatologic manifestations. This report serves to highlight the importance of dermatologic findings in underlying leukemia and educate healthcare providers on the diagnosis and treatment of a rare TP53 mutation in AML.
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spelling pubmed-101509392023-05-02 Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations Lott, Ronald Stawitzky, Sara Stroia, Alexandra Awad, Angela Kam, Anthony Bleicher, Maxim Cureus Internal Medicine Acute myeloid leukemia (AML) is a complex and aggressive malignancy that occurs due to genetic mutations and subsequent stem cell overproduction. We report a case of a patient with AML and a highly fatal, uncommon TP53 mutation who developed dermatologic manifestations. This report serves to highlight the importance of dermatologic findings in underlying leukemia and educate healthcare providers on the diagnosis and treatment of a rare TP53 mutation in AML. Cureus 2023-04-01 /pmc/articles/PMC10150939/ /pubmed/37139024 http://dx.doi.org/10.7759/cureus.37012 Text en Copyright © 2023, Lott et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Lott, Ronald
Stawitzky, Sara
Stroia, Alexandra
Awad, Angela
Kam, Anthony
Bleicher, Maxim
Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations
title Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations
title_full Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations
title_fullStr Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations
title_full_unstemmed Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations
title_short Rare Presentation of Acute Myeloid Leukemia With TP53 Mutation and Dermatologic Manifestations
title_sort rare presentation of acute myeloid leukemia with tp53 mutation and dermatologic manifestations
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150939/
https://www.ncbi.nlm.nih.gov/pubmed/37139024
http://dx.doi.org/10.7759/cureus.37012
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