Cargando…

Genomic and structural basis for evolution of tropane alkaloid biosynthesis

The tropane alkaloids (TAs) cocaine and hyoscyamine have been used medicinally for thousands of years. To understand the evolutionary origins and trajectories of serial biosynthetic enzymes of TAs and especially the characteristic tropane skeletons, we generated the chromosome-level genome assemblie...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Yong-Jiang, Tain, Tian, Yu, Jia-Yi, Li, Jie, Xu, Bingyan, Chen, Jianghua, D’Auria, John C., Huang, Jian-Ping, Huang, Sheng-Xiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151470/ https://www.ncbi.nlm.nih.gov/pubmed/37068250 http://dx.doi.org/10.1073/pnas.2302448120

Ejemplares similares

Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform
por: Chavez, Benjamin G., et al.
Publicado: (2022)

Tropane and Granatane Alkaloid Biosynthesis: A Systematic Analysis
por: Kim, Neill, et al.
Publicado: (2016)

Biosynthesis of medicinal tropane alkaloids in yeast
por: Srinivasan, Prashanth, et al.
Publicado: (2020)

Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production
por: Kohnen-Johannsen, Kathrin Laura, et al.
Publicado: (2019)

Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation
por: Huang, Jian-Ping, et al.
Publicado: (2019)

Revealing evolution of tropane alkaloid biosynthesis by analyzing two genomes in the Solanaceae family
por: Zhang, Fangyuan, et al.
Publicado: (2023)

Metabolic Effects of Elicitors on the Biosynthesis of Tropane Alkaloids in Medicinal Plants
por: Wen, Yuru, et al.
Publicado: (2023)

Biotechnological Approaches on Engineering Medicinal Tropane Alkaloid Production in Plants
por: Gong, Haiyue, et al.
Publicado: (2022)

Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
por: Dey, Prasanta, et al.
Publicado: (2020)

Engineering a microbial biosynthesis platform for de novo production of tropane alkaloids
por: Srinivasan, Prashanth, et al.
Publicado: (2019)

Chirality and Numbering of Substituted Tropane Alkaloids
por: Humam, Munir, et al.
Publicado: (2011)

Rapid Synthesis of Psychoplastogenic Tropane Alkaloids
por: Chow, Winston L., et al.
Publicado: (2023)

Human acute exposure assessment to tropane alkaloids
por: Arcella, Davide, et al.
Publicado: (2018)

Beauty of the beast: anticholinergic tropane alkaloids in therapeutics
por: Shim, Kyu Hwan, et al.
Publicado: (2022)

Emerging Issues on Tropane Alkaloid Contamination of Food in Europe
por: de Nijs, Monique, et al.
Publicado: (2023)

Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna
por: Parks, Hannah M., et al.
Publicado: (2022)

Metabolomics-guided discovery of cytochrome P450s involved in pseudotropine-dependent biosynthesis of modified tropane alkaloids
por: Sadre, Radin, et al.
Publicado: (2022)

Worldwide Occurrence and Investigations of Contamination of Herbal Medicines by Tropane Alkaloids
por: Chan, Thomas Y. K.
Publicado: (2017)

Tropane alkaloids and terpenes synthase genes of Datura stramonium (Solanaceae)
por: Velázquez-Márquez, Sabina, et al.
Publicado: (2021)

Selection on tropane alkaloids in native and non‐native populations of Datura stramonium
por: Castillo, Guillermo, et al.
Publicado: (2019)

Development of CE-C(4)D Method for Determination Tropane Alkaloids
por: Gołąb, Małgorzata, et al.
Publicado: (2021)

Assessment of the Conclusions of the Joint FAO/WHO Expert Meeting on Tropane Alkaloids
por: Binaglia, Marco
Publicado: (2022)

Health concerns associated to tropane alkaloids in maize food products in Serbia
por: Torović, Ljilja, et al.
Publicado: (2023)

Complete biosynthesis of the bisbenzylisoquinoline alkaloids guattegaumerine and berbamunine in yeast
por: Payne, James T., et al.
Publicado: (2021)

Ipvelutine, 7β-Acetoxy-2α-(tigloyloxy)tropane, an Unusual Tropane Alkaloid from Ipomoea velutina R. Br. (Convolvulaceae)
por: Ott, Sonja Christina, et al.
Publicado: (2013)

Effects of Water Availability in the Soil on Tropane Alkaloid Production in Cultivated Datura stramonium
por: Moreno-Pedraza, Abigail, et al.
Publicado: (2019)

Simultaneous Determination of Pyrrolizidine and Tropane Alkaloids in Honey by Liquid Chromatography–mass Spectrometry
por: Kowalczyk, Ewelina, et al.
Publicado: (2022)

Targeted expression of Vitreoscilla hemoglobin improves the production of tropane alkaloids in Hyoscyamus niger hairy roots
por: Guo, Zhiying, et al.
Publicado: (2018)

Enhancing Tropane Alkaloid Production Based on the Functional Identification of Tropine-Forming Reductase in Scopolia lurida, a Tibetan Medicinal Plant
por: Zhao, Kaihui, et al.
Publicado: (2017)

An analysis of Sorghum halepense’s behavior in presence of tropane alkaloids from Datura stramonium extracts
por: Butnariu, Monica
Publicado: (2012)

Tropane and related alkaloid skeletons via a radical [3+3]-annulation process
por: Colson, Eloïse, et al.
Publicado: (2022)

The Bright and Dark Sides of Herbal Infusions: Assessment of Antioxidant Capacity and Determination of Tropane Alkaloids
por: Mateus, Ana Rita Soares, et al.
Publicado: (2023)

Inorganic ions in the medium modify tropane alkaloids and riboflavin output in Hyoscyamus niger root cultures
por: Pudersell, Katrin, et al.
Publicado: (2012)

Co-expression of AaPMT and AaTRI effectively enhances the yields of tropane alkaloids in Anisodus acutangulus hairy roots
por: Kai, Guoyin, et al.
Publicado: (2011)

Structural Basis of Cycloaddition in Biosynthesis of Iboga and Aspidosperma Alkaloids
por: Caputi, Lorenzo, et al.
Publicado: (2020)

Ultrasonic Extraction of Tropane Alkaloids from Radix physochlainae Using as Extractant an Ionic Liquid with Similar Structure
por: Yohannes, Alula, et al.
Publicado: (2019)

Evaluation of Tropane Alkaloids in Teas and Herbal Infusions: Effect of Brewing Time and Temperature on Atropine and Scopolamine Content
por: González-Gómez, Lorena, et al.
Publicado: (2023)

A sensitive LC–MS/MS method for isomer separation and quantitative determination of 51 pyrrolizidine alkaloids and two tropane alkaloids in cow’s milk
por: Klein, Lisa Monika, et al.
Publicado: (2022)

Identification and Characterization of Genes Involved in Benzylisoquinoline Alkaloid Biosynthesis in Coptis Species
por: He, Si-Mei, et al.
Publicado: (2018)

Production of tropane alkaloids in Hyoscyamus niger (black henbane) hairy roots grown in bubble-column and spray bioreactors
por: Jaremicz, Zbigniew, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_u433ovckh5e3jdub9e216eh87d