Reprogramming by drug-like molecules leads to regeneration of cochlear hair cell–like cells in adult mice

Strategies to overcome irreversible cochlear hair cell (HC) damage and loss in mammals are of vital importance to hearing recovery in patients with permanent hearing loss. In mature mammalian cochlea, co-activation of Myc and Notch1 reprograms supporting cells (SC) and promotes HC regeneration. Unde...

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Detalles Bibliográficos
Autores principales: Quan, Yi-Zhou, Wei, Wei, Ergin, Volkan, Rameshbabu, Arun Prabhu, Huang, Mingqian, Tian, Chunjie, Saladi, Srinivas Vinod, Indzhykulian, Artur A., Chen, Zheng-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151514/
https://www.ncbi.nlm.nih.gov/pubmed/37068229
http://dx.doi.org/10.1073/pnas.2215253120

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