Berberine stimulates lysosomal AMPK independent of PEN2 and maintains cellular AMPK activity through inhibiting the dephosphorylation regulator UHRF1

Aim: AMPK is the key regulatory kinase mediating the effect of berberine (BBR) and metformin on metabolic improvement. The present study investigated the mechanism of BBR on AMPK activation at low doses, which was different from that of metformin. Methods: Lysosomes were isolated, and AMPK activity...

Descripción completa

Detalles Bibliográficos
Autores principales: Ren, Gang, Ding, Yu-Wei, Wang, Lu-Lu, Jiang, Jian-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151516/
https://www.ncbi.nlm.nih.gov/pubmed/37144221
http://dx.doi.org/10.3389/fphar.2023.1148611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151516/
https://www.ncbi.nlm.nih.gov/pubmed/37144221
http://dx.doi.org/10.3389/fphar.2023.1148611

Ejemplares similares