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NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity

Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly investigated particulates, MNPs may penetrate epithelial barriers, potentially triggering a cascade of signaling eve...

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Autores principales: Alijagic, Andi, Hedbrant, Alexander, Persson, Alexander, Larsson, Maria, Engwall, Magnus, Särndahl, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151538/
https://www.ncbi.nlm.nih.gov/pubmed/37143682
http://dx.doi.org/10.3389/fimmu.2023.1178434
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author Alijagic, Andi
Hedbrant, Alexander
Persson, Alexander
Larsson, Maria
Engwall, Magnus
Särndahl, Eva
author_facet Alijagic, Andi
Hedbrant, Alexander
Persson, Alexander
Larsson, Maria
Engwall, Magnus
Särndahl, Eva
author_sort Alijagic, Andi
collection PubMed
description Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly investigated particulates, MNPs may penetrate epithelial barriers, potentially triggering a cascade of signaling events leading to cell damage and inflammation. Inflammasomes are intracellular multiprotein complexes and stimulus-induced sensors critical for mounting inflammatory responses upon recognition of pathogen- or damage-associated molecular patterns. Among these, the NLRP3 inflammasome is the most studied in terms of activation via particulates. However, studies delineating the ability of MNPs to affect NLRP3 inflammasome activation are still rare. In this review, we address the issue of MNPs source and fate, highlight the main concepts of inflammasome activation via particulates, and explore recent advances in using inflammasome activation for assessment of MNP immunotoxicity. We also discuss the impact of co-exposure and MNP complex chemistry in potential inflammasome activation. Development of robust biological sensors is crucial in order to maximize global efforts to effectively address and mitigate risks that MNPs pose for human health.
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spelling pubmed-101515382023-05-03 NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity Alijagic, Andi Hedbrant, Alexander Persson, Alexander Larsson, Maria Engwall, Magnus Särndahl, Eva Front Immunol Immunology Micro- and nanoplastics (MNPs) are emerging pollutants with scarcely investigated effects on human innate immunity. If they follow a similar course of action as other, more thoroughly investigated particulates, MNPs may penetrate epithelial barriers, potentially triggering a cascade of signaling events leading to cell damage and inflammation. Inflammasomes are intracellular multiprotein complexes and stimulus-induced sensors critical for mounting inflammatory responses upon recognition of pathogen- or damage-associated molecular patterns. Among these, the NLRP3 inflammasome is the most studied in terms of activation via particulates. However, studies delineating the ability of MNPs to affect NLRP3 inflammasome activation are still rare. In this review, we address the issue of MNPs source and fate, highlight the main concepts of inflammasome activation via particulates, and explore recent advances in using inflammasome activation for assessment of MNP immunotoxicity. We also discuss the impact of co-exposure and MNP complex chemistry in potential inflammasome activation. Development of robust biological sensors is crucial in order to maximize global efforts to effectively address and mitigate risks that MNPs pose for human health. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151538/ /pubmed/37143682 http://dx.doi.org/10.3389/fimmu.2023.1178434 Text en Copyright © 2023 Alijagic, Hedbrant, Persson, Larsson, Engwall and Särndahl https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Alijagic, Andi
Hedbrant, Alexander
Persson, Alexander
Larsson, Maria
Engwall, Magnus
Särndahl, Eva
NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
title NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
title_full NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
title_fullStr NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
title_full_unstemmed NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
title_short NLRP3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
title_sort nlrp3 inflammasome as a sensor of micro- and nanoplastics immunotoxicity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151538/
https://www.ncbi.nlm.nih.gov/pubmed/37143682
http://dx.doi.org/10.3389/fimmu.2023.1178434
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