Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs

Cell-free DNA (cfDNA) fragmentation is nonrandom, at least partially mediated by various DNA nucleases, forming characteristic cfDNA end motifs. However, there is a paucity of tools for deciphering the relative contributions of cfDNA cleavage patterns related to underlying fragmentation factors. In...

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Detalles Bibliográficos
Autores principales: Zhou, Ze, Ma, Mary-Jane L., Chan, Rebecca W. Y., Lam, W. K. Jacky, Peng, Wenlei, Gai, Wanxia, Hu, Xi, Ding, Spencer C., Ji, Lu, Zhou, Qing, Cheung, Peter P. H., Yu, Stephanie C. Y., Teoh, Jeremy Y. C., Szeto, Cheuk-Chun, Wong, John, Wong, Vincent W. S., Wong, Grace L. H., Chan, Stephen L., Hui, Edwin P., Ma, Brigette B. Y., Chan, Anthony T. C., Chiu, Rossa W. K., Chan, K. C. Allen, Lo, Y. M. Dennis, Jiang, Peiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151549/
https://www.ncbi.nlm.nih.gov/pubmed/37075072
http://dx.doi.org/10.1073/pnas.2220982120

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