An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review

Thioredoxin-interacting protein (TXNIP) was first isolated from Vitamin D3-exposed HL60 cells. TXNIP is the main redox-regulating factor in various organs and tissues. We begin with an overview of the TXNIP gene and protein information, followed by a summary of studies that have shown its expression...

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Detalles Bibliográficos
Autores principales: Sun, Hong, Sun, Rong, Hua, Yulin, Lu, Qianyi, Shao, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151556/
https://www.ncbi.nlm.nih.gov/pubmed/37144033
http://dx.doi.org/10.3389/fmed.2023.1153805
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author Sun, Hong
Sun, Rong
Hua, Yulin
Lu, Qianyi
Shao, Xinyu
author_facet Sun, Hong
Sun, Rong
Hua, Yulin
Lu, Qianyi
Shao, Xinyu
author_sort Sun, Hong
collection PubMed
description Thioredoxin-interacting protein (TXNIP) was first isolated from Vitamin D3-exposed HL60 cells. TXNIP is the main redox-regulating factor in various organs and tissues. We begin with an overview of the TXNIP gene and protein information, followed by a summary of studies that have shown its expression in human kidneys. Then, we highlight our current understanding of the effect of TXNIP on diabetic kidney disease (DKD) to improve our understanding of the biological roles and signal transduction of TXNIP in DKD. Based on the recent review, the modulation of TXNIP may be considered as a new target in the management of DKD.
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spelling pubmed-101515562023-05-03 An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review Sun, Hong Sun, Rong Hua, Yulin Lu, Qianyi Shao, Xinyu Front Med (Lausanne) Medicine Thioredoxin-interacting protein (TXNIP) was first isolated from Vitamin D3-exposed HL60 cells. TXNIP is the main redox-regulating factor in various organs and tissues. We begin with an overview of the TXNIP gene and protein information, followed by a summary of studies that have shown its expression in human kidneys. Then, we highlight our current understanding of the effect of TXNIP on diabetic kidney disease (DKD) to improve our understanding of the biological roles and signal transduction of TXNIP in DKD. Based on the recent review, the modulation of TXNIP may be considered as a new target in the management of DKD. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151556/ /pubmed/37144033 http://dx.doi.org/10.3389/fmed.2023.1153805 Text en Copyright © 2023 Sun, Sun, Hua, Lu and Shao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Sun, Hong
Sun, Rong
Hua, Yulin
Lu, Qianyi
Shao, Xinyu
An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
title An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
title_full An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
title_fullStr An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
title_full_unstemmed An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
title_short An update on the role of thioredoxin-interacting protein in diabetic kidney disease: A mini review
title_sort update on the role of thioredoxin-interacting protein in diabetic kidney disease: a mini review
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151556/
https://www.ncbi.nlm.nih.gov/pubmed/37144033
http://dx.doi.org/10.3389/fmed.2023.1153805
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