The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis

Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation and is overexpressed in lesional skin of AD patients. Upon release in peripheral skin, IL-13 activates its receptors,...

Descripción completa

Detalles Bibliográficos
Autores principales: Napolitano, Maddalena, di Vico, Francesca, Ruggiero, Angelo, Fabbrocini, Gabriella, Patruno, Cataldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151557/
https://www.ncbi.nlm.nih.gov/pubmed/37144036
http://dx.doi.org/10.3389/fmed.2023.1165098
_version_ 1785035561817341952
author Napolitano, Maddalena
di Vico, Francesca
Ruggiero, Angelo
Fabbrocini, Gabriella
Patruno, Cataldo
author_facet Napolitano, Maddalena
di Vico, Francesca
Ruggiero, Angelo
Fabbrocini, Gabriella
Patruno, Cataldo
author_sort Napolitano, Maddalena
collection PubMed
description Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation and is overexpressed in lesional skin of AD patients. Upon release in peripheral skin, IL-13 activates its receptors, recruits inflammatory cells, and modifies the skin microbiome. IL-13 also reduces the expression of epidermal barrier proteins and activates sensory nerve mediating the itch transmission signal. Novel therapeutics that target IL-13 seem to be efficacious and safe for the treatment of patients with moderate-to-severe AD. The aim of our manuscript is to review the role that IL-13 plays in AD immunopathogenesis.
format Online
Article
Text
id pubmed-10151557
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-101515572023-05-03 The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis Napolitano, Maddalena di Vico, Francesca Ruggiero, Angelo Fabbrocini, Gabriella Patruno, Cataldo Front Med (Lausanne) Medicine Recent evidence suggests that interleukin (IL)-13 is a crucial cytokine involved in the pathogenesis of atopic dermatitis (AD). It is a central driver of type-2 T-helper inflammation and is overexpressed in lesional skin of AD patients. Upon release in peripheral skin, IL-13 activates its receptors, recruits inflammatory cells, and modifies the skin microbiome. IL-13 also reduces the expression of epidermal barrier proteins and activates sensory nerve mediating the itch transmission signal. Novel therapeutics that target IL-13 seem to be efficacious and safe for the treatment of patients with moderate-to-severe AD. The aim of our manuscript is to review the role that IL-13 plays in AD immunopathogenesis. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151557/ /pubmed/37144036 http://dx.doi.org/10.3389/fmed.2023.1165098 Text en Copyright © 2023 Napolitano, di Vico, Ruggiero, Fabbrocini and Patruno. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Napolitano, Maddalena
di Vico, Francesca
Ruggiero, Angelo
Fabbrocini, Gabriella
Patruno, Cataldo
The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
title The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
title_full The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
title_fullStr The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
title_full_unstemmed The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
title_short The hidden sentinel of the skin: An overview on the role of interleukin-13 in atopic dermatitis
title_sort hidden sentinel of the skin: an overview on the role of interleukin-13 in atopic dermatitis
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151557/
https://www.ncbi.nlm.nih.gov/pubmed/37144036
http://dx.doi.org/10.3389/fmed.2023.1165098
work_keys_str_mv AT napolitanomaddalena thehiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT divicofrancesca thehiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT ruggieroangelo thehiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT fabbrocinigabriella thehiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT patrunocataldo thehiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT napolitanomaddalena hiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT divicofrancesca hiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT ruggieroangelo hiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT fabbrocinigabriella hiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis
AT patrunocataldo hiddensentineloftheskinanoverviewontheroleofinterleukin13inatopicdermatitis

Ejemplares similares