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Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras

BACKGROUND: The migrainous aura has different clinical phenotypes. While the various clinical differences are well-described, little is known about their neurophysiological underpinnings. To elucidate the latter, we compared white matter fiber bundles and gray matter cortical thickness between healt...

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Autores principales: Abagnale, Chiara, Di Renzo, Antonio, Sebastianelli, Gabriele, Casillo, Francesco, Tinelli, Emanuele, Giuliani, Giada, Tullo, Maria Giulia, Serrao, Mariano, Parisi, Vincenzo, Fiorelli, Marco, Caramia, Francesca, Schoenen, Jean, Di Piero, Vittorio, Coppola, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151576/
https://www.ncbi.nlm.nih.gov/pubmed/37144161
http://dx.doi.org/10.3389/fnhum.2023.1146302
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author Abagnale, Chiara
Di Renzo, Antonio
Sebastianelli, Gabriele
Casillo, Francesco
Tinelli, Emanuele
Giuliani, Giada
Tullo, Maria Giulia
Serrao, Mariano
Parisi, Vincenzo
Fiorelli, Marco
Caramia, Francesca
Schoenen, Jean
Di Piero, Vittorio
Coppola, Gianluca
author_facet Abagnale, Chiara
Di Renzo, Antonio
Sebastianelli, Gabriele
Casillo, Francesco
Tinelli, Emanuele
Giuliani, Giada
Tullo, Maria Giulia
Serrao, Mariano
Parisi, Vincenzo
Fiorelli, Marco
Caramia, Francesca
Schoenen, Jean
Di Piero, Vittorio
Coppola, Gianluca
author_sort Abagnale, Chiara
collection PubMed
description BACKGROUND: The migrainous aura has different clinical phenotypes. While the various clinical differences are well-described, little is known about their neurophysiological underpinnings. To elucidate the latter, we compared white matter fiber bundles and gray matter cortical thickness between healthy controls (HC), patients with pure visual auras (MA) and patients with complex neurological auras (MA+). METHODS: 3T MRI data were collected between attacks from 20 patients with MA and 15 with MA+, and compared with those from 19 HCs. We analyzed white matter fiber bundles using tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) and cortical thickness with surface-based morphometry of structural MRI data. RESULTS: Tract-based spatial statistics showed no significant difference in diffusivity maps between the three subject groups. As compared to HCs, both MA and MA+ patients had significant cortical thinning in temporal, frontal, insular, postcentral, primary and associative visual areas. In the MA group, the right high-level visual-information-processing areas, including lingual gyrus, and the Rolandic operculum were thicker than in HCs, while in the MA+ group they were thinner. DISCUSSION: These findings show that migraine with aura is associated with cortical thinning in multiple cortical areas and that the clinical heterogeneity of the aura is reflected by opposite thickness changes in high-level visual-information-processing, sensorimotor and language areas.
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spelling pubmed-101515762023-05-03 Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras Abagnale, Chiara Di Renzo, Antonio Sebastianelli, Gabriele Casillo, Francesco Tinelli, Emanuele Giuliani, Giada Tullo, Maria Giulia Serrao, Mariano Parisi, Vincenzo Fiorelli, Marco Caramia, Francesca Schoenen, Jean Di Piero, Vittorio Coppola, Gianluca Front Hum Neurosci Neuroscience BACKGROUND: The migrainous aura has different clinical phenotypes. While the various clinical differences are well-described, little is known about their neurophysiological underpinnings. To elucidate the latter, we compared white matter fiber bundles and gray matter cortical thickness between healthy controls (HC), patients with pure visual auras (MA) and patients with complex neurological auras (MA+). METHODS: 3T MRI data were collected between attacks from 20 patients with MA and 15 with MA+, and compared with those from 19 HCs. We analyzed white matter fiber bundles using tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI) and cortical thickness with surface-based morphometry of structural MRI data. RESULTS: Tract-based spatial statistics showed no significant difference in diffusivity maps between the three subject groups. As compared to HCs, both MA and MA+ patients had significant cortical thinning in temporal, frontal, insular, postcentral, primary and associative visual areas. In the MA group, the right high-level visual-information-processing areas, including lingual gyrus, and the Rolandic operculum were thicker than in HCs, while in the MA+ group they were thinner. DISCUSSION: These findings show that migraine with aura is associated with cortical thinning in multiple cortical areas and that the clinical heterogeneity of the aura is reflected by opposite thickness changes in high-level visual-information-processing, sensorimotor and language areas. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151576/ /pubmed/37144161 http://dx.doi.org/10.3389/fnhum.2023.1146302 Text en Copyright © 2023 Abagnale, Di Renzo, Sebastianelli, Casillo, Tinelli, Giuliani, Tullo, Serrao, Parisi, Fiorelli, Caramia, Schoenen, Di Piero and Coppola. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Abagnale, Chiara
Di Renzo, Antonio
Sebastianelli, Gabriele
Casillo, Francesco
Tinelli, Emanuele
Giuliani, Giada
Tullo, Maria Giulia
Serrao, Mariano
Parisi, Vincenzo
Fiorelli, Marco
Caramia, Francesca
Schoenen, Jean
Di Piero, Vittorio
Coppola, Gianluca
Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
title Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
title_full Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
title_fullStr Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
title_full_unstemmed Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
title_short Whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
title_sort whole brain surface-based morphometry and tract-based spatial statistics in migraine with aura patients: difference between pure visual and complex auras
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151576/
https://www.ncbi.nlm.nih.gov/pubmed/37144161
http://dx.doi.org/10.3389/fnhum.2023.1146302
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