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Vestibular physiology and function in zebrafish

The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear that serve as peripheral vestibular organs, with the addition o...

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Autores principales: Baeza-Loya, Selina, Raible, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151581/
https://www.ncbi.nlm.nih.gov/pubmed/37143895
http://dx.doi.org/10.3389/fcell.2023.1172933
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author Baeza-Loya, Selina
Raible, David W.
author_facet Baeza-Loya, Selina
Raible, David W.
author_sort Baeza-Loya, Selina
collection PubMed
description The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear that serve as peripheral vestibular organs, with the addition of the lagena and macula neglecta. The zebrafish inner ear can be easily studied due to its accessible location, the transparent tissue of larval fish, and the early development of vestibular behaviors. Thus, zebrafish are an excellent model for studying the development, physiology, and function of the vestibular system. Recent work has made great strides to elucidate vestibular neural circuitry in fish, tracing sensory transmission from receptors in the periphery to central computational circuits driving vestibular reflexes. Here we highlight recent work that illuminates the functional organization of vestibular sensory epithelia, innervating first-order afferent neurons, and second-order neuronal targets in the hindbrain. Using a combination of genetic, anatomical, electrophysiological, and optical techniques, these studies have probed the roles of vestibular sensory signals in fish gaze, postural, and swimming behaviors. We discuss remaining questions in vestibular development and organization that are tractable in the zebrafish model.
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spelling pubmed-101515812023-05-03 Vestibular physiology and function in zebrafish Baeza-Loya, Selina Raible, David W. Front Cell Dev Biol Cell and Developmental Biology The vestibular system of the inner ear provides information about head motion and spatial orientation relative to gravity to ensure gaze stability, balance, and postural control. Zebrafish, like humans, have five sensory patches per ear that serve as peripheral vestibular organs, with the addition of the lagena and macula neglecta. The zebrafish inner ear can be easily studied due to its accessible location, the transparent tissue of larval fish, and the early development of vestibular behaviors. Thus, zebrafish are an excellent model for studying the development, physiology, and function of the vestibular system. Recent work has made great strides to elucidate vestibular neural circuitry in fish, tracing sensory transmission from receptors in the periphery to central computational circuits driving vestibular reflexes. Here we highlight recent work that illuminates the functional organization of vestibular sensory epithelia, innervating first-order afferent neurons, and second-order neuronal targets in the hindbrain. Using a combination of genetic, anatomical, electrophysiological, and optical techniques, these studies have probed the roles of vestibular sensory signals in fish gaze, postural, and swimming behaviors. We discuss remaining questions in vestibular development and organization that are tractable in the zebrafish model. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151581/ /pubmed/37143895 http://dx.doi.org/10.3389/fcell.2023.1172933 Text en Copyright © 2023 Baeza-Loya and Raible. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Baeza-Loya, Selina
Raible, David W.
Vestibular physiology and function in zebrafish
title Vestibular physiology and function in zebrafish
title_full Vestibular physiology and function in zebrafish
title_fullStr Vestibular physiology and function in zebrafish
title_full_unstemmed Vestibular physiology and function in zebrafish
title_short Vestibular physiology and function in zebrafish
title_sort vestibular physiology and function in zebrafish
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151581/
https://www.ncbi.nlm.nih.gov/pubmed/37143895
http://dx.doi.org/10.3389/fcell.2023.1172933
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