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Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory

Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are crit...

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Autores principales: Scott, Adrienne K., Rafuse, Michael, Neu, Corey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151697/
https://www.ncbi.nlm.nih.gov/pubmed/37143893
http://dx.doi.org/10.3389/fcell.2023.1084759
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author Scott, Adrienne K.
Rafuse, Michael
Neu, Corey P.
author_facet Scott, Adrienne K.
Rafuse, Michael
Neu, Corey P.
author_sort Scott, Adrienne K.
collection PubMed
description Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are critical environmental cues that influence phenotypic plasticity and stability. Furthermore, an exposure to a prior mechanical signal has been demonstrated to play a fundamental role in modulating phenotypic changes that persist even after the mechanical stimulus is removed, creating stable mechanical memories. In this mini review, our objective is to highlight how the mechanical environment alters both phenotypic plasticity and stable memories through changes in chromatin architecture, mainly focusing on examples in cardiac tissue. We first explore how cell phenotypic plasticity is modulated in response to changes in the mechanical environment, and then connect the changes in phenotypic plasticity to changes in chromatin architecture that reflect short-term and long-term memories. Finally, we discuss how elucidating the mechanisms behind mechanically induced chromatin architecture that lead to cell adaptations and retention of stable mechanical memories could uncover treatment methods to prevent mal-adaptive permanent disease states.
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spelling pubmed-101516972023-05-03 Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory Scott, Adrienne K. Rafuse, Michael Neu, Corey P. Front Cell Dev Biol Cell and Developmental Biology Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are critical environmental cues that influence phenotypic plasticity and stability. Furthermore, an exposure to a prior mechanical signal has been demonstrated to play a fundamental role in modulating phenotypic changes that persist even after the mechanical stimulus is removed, creating stable mechanical memories. In this mini review, our objective is to highlight how the mechanical environment alters both phenotypic plasticity and stable memories through changes in chromatin architecture, mainly focusing on examples in cardiac tissue. We first explore how cell phenotypic plasticity is modulated in response to changes in the mechanical environment, and then connect the changes in phenotypic plasticity to changes in chromatin architecture that reflect short-term and long-term memories. Finally, we discuss how elucidating the mechanisms behind mechanically induced chromatin architecture that lead to cell adaptations and retention of stable mechanical memories could uncover treatment methods to prevent mal-adaptive permanent disease states. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151697/ /pubmed/37143893 http://dx.doi.org/10.3389/fcell.2023.1084759 Text en Copyright © 2023 Scott, Rafuse and Neu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Scott, Adrienne K.
Rafuse, Michael
Neu, Corey P.
Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
title Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
title_full Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
title_fullStr Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
title_full_unstemmed Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
title_short Mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
title_sort mechanically induced alterations in chromatin architecture guide the balance between cell plasticity and mechanical memory
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151697/
https://www.ncbi.nlm.nih.gov/pubmed/37143893
http://dx.doi.org/10.3389/fcell.2023.1084759
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