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Insights into IGH clonal evolution in BCP-ALL: frequency, mechanisms, associations, and diagnostic implications

INTRODUCTION: The malignant transformation leading to a maturation arrest in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) occurs early in B-cell development, in a pro-B or pre-B cell, when somatic recombination of variable (V), diversity (D), and joining (J) segment immunoglobulin (IG) ge...

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Detalles Bibliográficos
Autores principales:	Darzentas, Franziska, Szczepanowski, Monika, Kotrová, Michaela, Hartmann, Alina, Beder, Thomas, Gökbuget, Nicola, Schwartz, Stefan, Bastian, Lorenz, Baldus, Claudia Dorothea, Pál, Karol, Darzentas, Nikos, Brüggemann, Monika
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151743/ https://www.ncbi.nlm.nih.gov/pubmed/37143651 http://dx.doi.org/10.3389/fimmu.2023.1125017

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