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The generation, activation, and polarization of monocyte-derived macrophages in human malignancies

Macrophages are immune cells that originate from embryogenesis or from the differentiation of monocytes. They can adopt numerous phenotypes depending on their origin, tissue distribution and in response to different stimuli and tissue environment. Thus, in vivo, macrophages are endowed with a contin...

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Autores principales: Chaintreuil, Paul, Kerreneur, Emeline, Bourgoin, Maxence, Savy, Coline, Favreau, Cécile, Robert, Guillaume, Jacquel, Arnaud, Auberger, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151765/
https://www.ncbi.nlm.nih.gov/pubmed/37143666
http://dx.doi.org/10.3389/fimmu.2023.1178337
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author Chaintreuil, Paul
Kerreneur, Emeline
Bourgoin, Maxence
Savy, Coline
Favreau, Cécile
Robert, Guillaume
Jacquel, Arnaud
Auberger, Patrick
author_facet Chaintreuil, Paul
Kerreneur, Emeline
Bourgoin, Maxence
Savy, Coline
Favreau, Cécile
Robert, Guillaume
Jacquel, Arnaud
Auberger, Patrick
author_sort Chaintreuil, Paul
collection PubMed
description Macrophages are immune cells that originate from embryogenesis or from the differentiation of monocytes. They can adopt numerous phenotypes depending on their origin, tissue distribution and in response to different stimuli and tissue environment. Thus, in vivo, macrophages are endowed with a continuum of phenotypes that are rarely strictly pro-inflammatory or anti-inflammatory and exhibit a broad expression profile that sweeps over the whole polarization spectrum. Schematically, three main macrophage subpopulations coexist in human tissues: naïve macrophages also called M0, pro-inflammatory macrophages referred as M1 macrophages, and anti-inflammatory macrophages also known as M2 macrophages. Naïve macrophages display phagocytic functions, recognize pathogenic agents, and rapidly undergo polarization towards pro or anti-inflammatory macrophages to acquire their full panel of functions. Pro-inflammatory macrophages are widely involved in inflammatory response, during which they exert anti-microbial and anti-tumoral functions. By contrast, anti-inflammatory macrophages are implicated in the resolution of inflammation, the phagocytosis of cell debris and tissue reparation following injuries. Macrophages also play important deleterious or beneficial roles in the initiation and progression of different pathophysiological settings including solid and hematopoietic cancers. A better understanding of the molecular mechanisms involved in the generation, activation and polarization of macrophages is a prerequisite for the development of new therapeutic strategies to modulate macrophages functions in pathological situations.
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spelling pubmed-101517652023-05-03 The generation, activation, and polarization of monocyte-derived macrophages in human malignancies Chaintreuil, Paul Kerreneur, Emeline Bourgoin, Maxence Savy, Coline Favreau, Cécile Robert, Guillaume Jacquel, Arnaud Auberger, Patrick Front Immunol Immunology Macrophages are immune cells that originate from embryogenesis or from the differentiation of monocytes. They can adopt numerous phenotypes depending on their origin, tissue distribution and in response to different stimuli and tissue environment. Thus, in vivo, macrophages are endowed with a continuum of phenotypes that are rarely strictly pro-inflammatory or anti-inflammatory and exhibit a broad expression profile that sweeps over the whole polarization spectrum. Schematically, three main macrophage subpopulations coexist in human tissues: naïve macrophages also called M0, pro-inflammatory macrophages referred as M1 macrophages, and anti-inflammatory macrophages also known as M2 macrophages. Naïve macrophages display phagocytic functions, recognize pathogenic agents, and rapidly undergo polarization towards pro or anti-inflammatory macrophages to acquire their full panel of functions. Pro-inflammatory macrophages are widely involved in inflammatory response, during which they exert anti-microbial and anti-tumoral functions. By contrast, anti-inflammatory macrophages are implicated in the resolution of inflammation, the phagocytosis of cell debris and tissue reparation following injuries. Macrophages also play important deleterious or beneficial roles in the initiation and progression of different pathophysiological settings including solid and hematopoietic cancers. A better understanding of the molecular mechanisms involved in the generation, activation and polarization of macrophages is a prerequisite for the development of new therapeutic strategies to modulate macrophages functions in pathological situations. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151765/ /pubmed/37143666 http://dx.doi.org/10.3389/fimmu.2023.1178337 Text en Copyright © 2023 Chaintreuil, Kerreneur, Bourgoin, Savy, Favreau, Robert, Jacquel and Auberger https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chaintreuil, Paul
Kerreneur, Emeline
Bourgoin, Maxence
Savy, Coline
Favreau, Cécile
Robert, Guillaume
Jacquel, Arnaud
Auberger, Patrick
The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
title The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
title_full The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
title_fullStr The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
title_full_unstemmed The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
title_short The generation, activation, and polarization of monocyte-derived macrophages in human malignancies
title_sort generation, activation, and polarization of monocyte-derived macrophages in human malignancies
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151765/
https://www.ncbi.nlm.nih.gov/pubmed/37143666
http://dx.doi.org/10.3389/fimmu.2023.1178337
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