Cargando…
The mechanism of chronic intracellular infection with Brucella spp.
Globally, brucellosis is a widespread zoonotic disease. It is prevalent in more than 170 countries and regions. It mostly damages an animal’s reproductive system and causes extreme economic losses to the animal husbandry industry. Once inside cells, Brucella resides in a vacuole, designated the BCV,...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151771/ https://www.ncbi.nlm.nih.gov/pubmed/37143745 http://dx.doi.org/10.3389/fcimb.2023.1129172 |
_version_ | 1785035612133261312 |
---|---|
author | Guo, Xiaoyi Zeng, Hui Li, Mengjuan Xiao, Yu Gu, Guojing Song, Zhenhui Shuai, Xuehong Guo, Jianhua Huang, Qingzhou Zhou, Bo Chu, Yuefeng Jiao, Hanwei |
author_facet | Guo, Xiaoyi Zeng, Hui Li, Mengjuan Xiao, Yu Gu, Guojing Song, Zhenhui Shuai, Xuehong Guo, Jianhua Huang, Qingzhou Zhou, Bo Chu, Yuefeng Jiao, Hanwei |
author_sort | Guo, Xiaoyi |
collection | PubMed |
description | Globally, brucellosis is a widespread zoonotic disease. It is prevalent in more than 170 countries and regions. It mostly damages an animal’s reproductive system and causes extreme economic losses to the animal husbandry industry. Once inside cells, Brucella resides in a vacuole, designated the BCV, which interacts with components of the endocytic and secretory pathways to ensure bacterial survival. Numerous studies conducted recently have revealed that Brucella’s ability to cause a chronic infection depends on how it interacts with the host. This paper describes the immune system, apoptosis, and metabolic control of host cells as part of the mechanism of Brucella survival in host cells. Brucella contributes to both the body’s non-specific and specific immunity during chronic infection, and it can aid in its survival by causing the body’s immune system to become suppressed. In addition, Brucella regulates apoptosis to avoid being detected by the host immune system. The BvrR/BvrS, VjbR, BlxR, and BPE123 proteins enable Brucella to fine-tune its metabolism while also ensuring its survival and replication and improving its ability to adapt to the intracellular environment. |
format | Online Article Text |
id | pubmed-10151771 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101517712023-05-03 The mechanism of chronic intracellular infection with Brucella spp. Guo, Xiaoyi Zeng, Hui Li, Mengjuan Xiao, Yu Gu, Guojing Song, Zhenhui Shuai, Xuehong Guo, Jianhua Huang, Qingzhou Zhou, Bo Chu, Yuefeng Jiao, Hanwei Front Cell Infect Microbiol Cellular and Infection Microbiology Globally, brucellosis is a widespread zoonotic disease. It is prevalent in more than 170 countries and regions. It mostly damages an animal’s reproductive system and causes extreme economic losses to the animal husbandry industry. Once inside cells, Brucella resides in a vacuole, designated the BCV, which interacts with components of the endocytic and secretory pathways to ensure bacterial survival. Numerous studies conducted recently have revealed that Brucella’s ability to cause a chronic infection depends on how it interacts with the host. This paper describes the immune system, apoptosis, and metabolic control of host cells as part of the mechanism of Brucella survival in host cells. Brucella contributes to both the body’s non-specific and specific immunity during chronic infection, and it can aid in its survival by causing the body’s immune system to become suppressed. In addition, Brucella regulates apoptosis to avoid being detected by the host immune system. The BvrR/BvrS, VjbR, BlxR, and BPE123 proteins enable Brucella to fine-tune its metabolism while also ensuring its survival and replication and improving its ability to adapt to the intracellular environment. Frontiers Media S.A. 2023-04-18 /pmc/articles/PMC10151771/ /pubmed/37143745 http://dx.doi.org/10.3389/fcimb.2023.1129172 Text en Copyright © 2023 Guo, Zeng, Li, Xiao, Gu, Song, Shuai, Guo, Huang, Zhou, Chu and Jiao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Guo, Xiaoyi Zeng, Hui Li, Mengjuan Xiao, Yu Gu, Guojing Song, Zhenhui Shuai, Xuehong Guo, Jianhua Huang, Qingzhou Zhou, Bo Chu, Yuefeng Jiao, Hanwei The mechanism of chronic intracellular infection with Brucella spp. |
title | The mechanism of chronic intracellular infection with Brucella spp. |
title_full | The mechanism of chronic intracellular infection with Brucella spp. |
title_fullStr | The mechanism of chronic intracellular infection with Brucella spp. |
title_full_unstemmed | The mechanism of chronic intracellular infection with Brucella spp. |
title_short | The mechanism of chronic intracellular infection with Brucella spp. |
title_sort | mechanism of chronic intracellular infection with brucella spp. |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151771/ https://www.ncbi.nlm.nih.gov/pubmed/37143745 http://dx.doi.org/10.3389/fcimb.2023.1129172 |
work_keys_str_mv | AT guoxiaoyi themechanismofchronicintracellularinfectionwithbrucellaspp AT zenghui themechanismofchronicintracellularinfectionwithbrucellaspp AT limengjuan themechanismofchronicintracellularinfectionwithbrucellaspp AT xiaoyu themechanismofchronicintracellularinfectionwithbrucellaspp AT guguojing themechanismofchronicintracellularinfectionwithbrucellaspp AT songzhenhui themechanismofchronicintracellularinfectionwithbrucellaspp AT shuaixuehong themechanismofchronicintracellularinfectionwithbrucellaspp AT guojianhua themechanismofchronicintracellularinfectionwithbrucellaspp AT huangqingzhou themechanismofchronicintracellularinfectionwithbrucellaspp AT zhoubo themechanismofchronicintracellularinfectionwithbrucellaspp AT chuyuefeng themechanismofchronicintracellularinfectionwithbrucellaspp AT jiaohanwei themechanismofchronicintracellularinfectionwithbrucellaspp AT guoxiaoyi mechanismofchronicintracellularinfectionwithbrucellaspp AT zenghui mechanismofchronicintracellularinfectionwithbrucellaspp AT limengjuan mechanismofchronicintracellularinfectionwithbrucellaspp AT xiaoyu mechanismofchronicintracellularinfectionwithbrucellaspp AT guguojing mechanismofchronicintracellularinfectionwithbrucellaspp AT songzhenhui mechanismofchronicintracellularinfectionwithbrucellaspp AT shuaixuehong mechanismofchronicintracellularinfectionwithbrucellaspp AT guojianhua mechanismofchronicintracellularinfectionwithbrucellaspp AT huangqingzhou mechanismofchronicintracellularinfectionwithbrucellaspp AT zhoubo mechanismofchronicintracellularinfectionwithbrucellaspp AT chuyuefeng mechanismofchronicintracellularinfectionwithbrucellaspp AT jiaohanwei mechanismofchronicintracellularinfectionwithbrucellaspp |