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Safety and efficacy of the tumor-selective adenovirus enadenotucirev, in combination with nivolumab, in patients with advanced/metastatic epithelial cancer: a phase I clinical trial (SPICE)

BACKGROUND: Novel combination therapies to overcome anti-PD-1 resistance are required. Enadenotucirev, a tumor-selective blood stable adenoviral vector, has demonstrated a manageable safety profile and ability to increase tumor immune-cell infiltration in phase I studies in solid tumors. METHODS: We...

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Detalles Bibliográficos
Autores principales:	Fakih, Marwan, Harb, Wael, Mahadevan, Daruka, Babiker, Hani, Berlin, Jordan, Lillie, Tom, Krige, David, Carter, Jo, Cox, Chris, Patel, Minesh, Parfitt, Lola, Powell, Mark, Rosen, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10151977/ https://www.ncbi.nlm.nih.gov/pubmed/37094988 http://dx.doi.org/10.1136/jitc-2022-006561

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