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Cognitive flexibility: neurobehavioral correlates of changing one’s mind

Behavioral and cognitive flexibility allow adaptation to a changing environment. Most tasks used to investigate flexibility require switching reactively in response to deterministic task-response rules. In daily life, flexibility often involves a volitional decision to change behavior. This can be i...

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Autores principales: Zühlsdorff, Katharina, Dalley, Jeffrey W, Robbins, Trevor W, Morein-Zamir, Sharon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152092/
https://www.ncbi.nlm.nih.gov/pubmed/36368894
http://dx.doi.org/10.1093/cercor/bhac431
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author Zühlsdorff, Katharina
Dalley, Jeffrey W
Robbins, Trevor W
Morein-Zamir, Sharon
author_facet Zühlsdorff, Katharina
Dalley, Jeffrey W
Robbins, Trevor W
Morein-Zamir, Sharon
author_sort Zühlsdorff, Katharina
collection PubMed
description Behavioral and cognitive flexibility allow adaptation to a changing environment. Most tasks used to investigate flexibility require switching reactively in response to deterministic task-response rules. In daily life, flexibility often involves a volitional decision to change behavior. This can be instigated by environmental signals, but these are frequently unreliable. We report results from a novel “change your mind” task, which assesses volitional switching under uncertainty without the need for rule-based learning. Participants completed a two-alternative choice task, and following spurious feedback, were presented with the same stimulus again. Subjects had the opportunity to repeat or change their response. Forty healthy participants completed the task while undergoing a functional magnetic resonance imaging scan. Participants predominantly repeated their choice but changed more when their first response was incorrect or when the feedback was negative. Greater activations for changing were found in the inferior frontal junction, anterior insula (AI), anterior cingulate, and dorsolateral prefrontal cortex. Changing responses were also accompanied by reduced connectivity from the AI and orbitofrontal cortices to the occipital cortex. Using multivariate pattern analysis of brain activity, we predicted with 77% reliability whether participants would change their mind. These findings extend our understanding of cognitive flexibility in daily life by assessing volitional decision-making.
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spelling pubmed-101520922023-05-03 Cognitive flexibility: neurobehavioral correlates of changing one’s mind Zühlsdorff, Katharina Dalley, Jeffrey W Robbins, Trevor W Morein-Zamir, Sharon Cereb Cortex Original Article Behavioral and cognitive flexibility allow adaptation to a changing environment. Most tasks used to investigate flexibility require switching reactively in response to deterministic task-response rules. In daily life, flexibility often involves a volitional decision to change behavior. This can be instigated by environmental signals, but these are frequently unreliable. We report results from a novel “change your mind” task, which assesses volitional switching under uncertainty without the need for rule-based learning. Participants completed a two-alternative choice task, and following spurious feedback, were presented with the same stimulus again. Subjects had the opportunity to repeat or change their response. Forty healthy participants completed the task while undergoing a functional magnetic resonance imaging scan. Participants predominantly repeated their choice but changed more when their first response was incorrect or when the feedback was negative. Greater activations for changing were found in the inferior frontal junction, anterior insula (AI), anterior cingulate, and dorsolateral prefrontal cortex. Changing responses were also accompanied by reduced connectivity from the AI and orbitofrontal cortices to the occipital cortex. Using multivariate pattern analysis of brain activity, we predicted with 77% reliability whether participants would change their mind. These findings extend our understanding of cognitive flexibility in daily life by assessing volitional decision-making. Oxford University Press 2022-11-11 /pmc/articles/PMC10152092/ /pubmed/36368894 http://dx.doi.org/10.1093/cercor/bhac431 Text en © The Author(s) 2022. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zühlsdorff, Katharina
Dalley, Jeffrey W
Robbins, Trevor W
Morein-Zamir, Sharon
Cognitive flexibility: neurobehavioral correlates of changing one’s mind
title Cognitive flexibility: neurobehavioral correlates of changing one’s mind
title_full Cognitive flexibility: neurobehavioral correlates of changing one’s mind
title_fullStr Cognitive flexibility: neurobehavioral correlates of changing one’s mind
title_full_unstemmed Cognitive flexibility: neurobehavioral correlates of changing one’s mind
title_short Cognitive flexibility: neurobehavioral correlates of changing one’s mind
title_sort cognitive flexibility: neurobehavioral correlates of changing one’s mind
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152092/
https://www.ncbi.nlm.nih.gov/pubmed/36368894
http://dx.doi.org/10.1093/cercor/bhac431
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