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Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats

BACKGROUND: The aim of this study was to investigate the prophylactic and therapeutic effects of Arum dioscoridis (tirsik) plant extract against thioacetamide-induced experimental liver toxicity. METHOD: s: In this study, 35 male Wistar–Albino rats, of 12-14 weeks old, weighing between 200 and 270 g...

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Autores principales: Fatih Sökmen, Murat, İspiroğlu, Murat, Gişi, Kadir, Yasir Bahar, Abdulkadir, Kurutaş, Ergül Belge, Kantarçeken, Bülent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Gastroenterology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152184/
https://www.ncbi.nlm.nih.gov/pubmed/36635913
http://dx.doi.org/10.5152/tjg.2023.211051
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author Fatih Sökmen, Murat
İspiroğlu, Murat
Gişi, Kadir
Yasir Bahar, Abdulkadir
Kurutaş, Ergül Belge
Kantarçeken, Bülent
author_facet Fatih Sökmen, Murat
İspiroğlu, Murat
Gişi, Kadir
Yasir Bahar, Abdulkadir
Kurutaş, Ergül Belge
Kantarçeken, Bülent
author_sort Fatih Sökmen, Murat
collection PubMed
description BACKGROUND: The aim of this study was to investigate the prophylactic and therapeutic effects of Arum dioscoridis (tirsik) plant extract against thioacetamide-induced experimental liver toxicity. METHOD: s: In this study, 35 male Wistar–Albino rats, of 12-14 weeks old, weighing between 200 and 270 g, were used. Rats were divided into 5 groups of 7 each. The first group was determined as the control group, the second group as the hepatotoxicity group, the third group as the prophylaxis group, the fourth group as the intraperitoneal treatment group, and the fifth group as the oral treatment group. Hepatotoxicity was achieved with a single intraperitoneal dose of 350 mg/kg of thioacetamide (TAA). On the seventh day, the rats were sacrificed under general anesthesia. Their blood was taken and liver enzymes were studied. Malondialdehyde (MDA), glutathyon peroxidase (GPx), catalase (CAT), superoxit dismutase (SOD) enzymes were studied from liver tissues. In addition, liver tissues were evaluated histopathologically. RESULTS: With Arum dioscoridis treatment and prophylaxis, improvements in all parameters and increases in tissue antioxidant levels were detected. CONCLUSION: It was determined that Arum dioscoridis plant extract has prophylactic and therapeutic effects on liver toxicity. In cases of acute liver injury and hepatotoxicity, we suggest the potential application of Arum dioscoridis for effective and inexpensive treatment.
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spelling pubmed-101521842023-05-03 Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats Fatih Sökmen, Murat İspiroğlu, Murat Gişi, Kadir Yasir Bahar, Abdulkadir Kurutaş, Ergül Belge Kantarçeken, Bülent Turk J Gastroenterol Original Article BACKGROUND: The aim of this study was to investigate the prophylactic and therapeutic effects of Arum dioscoridis (tirsik) plant extract against thioacetamide-induced experimental liver toxicity. METHOD: s: In this study, 35 male Wistar–Albino rats, of 12-14 weeks old, weighing between 200 and 270 g, were used. Rats were divided into 5 groups of 7 each. The first group was determined as the control group, the second group as the hepatotoxicity group, the third group as the prophylaxis group, the fourth group as the intraperitoneal treatment group, and the fifth group as the oral treatment group. Hepatotoxicity was achieved with a single intraperitoneal dose of 350 mg/kg of thioacetamide (TAA). On the seventh day, the rats were sacrificed under general anesthesia. Their blood was taken and liver enzymes were studied. Malondialdehyde (MDA), glutathyon peroxidase (GPx), catalase (CAT), superoxit dismutase (SOD) enzymes were studied from liver tissues. In addition, liver tissues were evaluated histopathologically. RESULTS: With Arum dioscoridis treatment and prophylaxis, improvements in all parameters and increases in tissue antioxidant levels were detected. CONCLUSION: It was determined that Arum dioscoridis plant extract has prophylactic and therapeutic effects on liver toxicity. In cases of acute liver injury and hepatotoxicity, we suggest the potential application of Arum dioscoridis for effective and inexpensive treatment. Turkish Society of Gastroenterology 2023-03-01 /pmc/articles/PMC10152184/ /pubmed/36635913 http://dx.doi.org/10.5152/tjg.2023.211051 Text en 2023 authors https://creativecommons.org/licenses/by/4.0/ Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Original Article
Fatih Sökmen, Murat
İspiroğlu, Murat
Gişi, Kadir
Yasir Bahar, Abdulkadir
Kurutaş, Ergül Belge
Kantarçeken, Bülent
Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats
title Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats
title_full Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats
title_fullStr Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats
title_full_unstemmed Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats
title_short Effects of Arum dioscoridis Extract on Hepatic Toxicity Caused by Thioacetamide in Rats
title_sort effects of arum dioscoridis extract on hepatic toxicity caused by thioacetamide in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152184/
https://www.ncbi.nlm.nih.gov/pubmed/36635913
http://dx.doi.org/10.5152/tjg.2023.211051
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