Comprehensive Metabolic Tracing Reveals the Origin and Catabolism of Cysteine in Mammalian Tissues and Tumors

Cysteine plays critical roles in cellular biosynthesis, enzyme catalysis, and redox metabolism. The intracellular cysteine pool can be sustained by cystine uptake or de novo synthesis from serine and homocysteine. Demand for cysteine is increased during tumorigenesis for generating glutathione to de...

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Detalles Bibliográficos
Autores principales: Yoon, Sang Jun, Combs, Joseph A., Falzone, Aimee, Prieto-Farigua, Nicolas, Caldwell, Samantha, Ackerman, Hayley D., Flores, Elsa R., DeNicola, Gina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Metabolism and Molecular Mechanisms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
https://www.ncbi.nlm.nih.gov/pubmed/36862034
http://dx.doi.org/10.1158/0008-5472.CAN-22-3000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10152234/
https://www.ncbi.nlm.nih.gov/pubmed/36862034
http://dx.doi.org/10.1158/0008-5472.CAN-22-3000

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